Project Grant R00DK135915
- Federal Project Grant Award Summary Florida State University's Sponsored Research Administration Division was awarded $2,782,476 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on September 1, 2025, with a completion date of August 31, 2029. The project delivers basic biomedical research aimed at elucidating the molecular mechanisms underlying pancreatic beta cell...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $1,453,844 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded August 20, 2025, with a completion date of June 30, 2030. This research initiative focuses on understanding chromatin remodeling factors and their mechanisms in diabetic microvascular complications...
- Federal Grant Award Summary Mayo Clinic received a $2,325,005 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 4, 2025, with completion targeted for August 31, 2029. The grant funds research investigating the role of extracellular vesicle and autophagy pathway crosstalk in Type 2 Diabetes (T2D) pathogenesis. The research project will...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Regents of the University of Colorado a Project Grant of $551,250 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on February 19, 2026, with completion scheduled for January 31, 2029. This research project focuses on elucidating the molecular mechanisms of vesicle fusion regulation in metabolic pathways, specifically examining how...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $786,216 Project Grant to the University of California, Los Angeles (UCLA) on August 28, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This four-year research initiative, concluding June 30, 2029, supports fundamental biomedical research investigating the post-transcriptional regulation of hepatokines and their role in systemic...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $803,748 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 5, 2025, with a completion date of June 30, 2029. This research grant supports a comprehensive investigation into modulation of insulin signaling in adipocytes to address systemic...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $847,746 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2030. This five-year research initiative focuses on investigating the role of the unfolded protein response (UPR) transducer XBP1 in pancreatic beta cell...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $641,794 Project Grant awarded July 21, 2025, through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The five-year award, with an ultimate completion date of April 30, 2030, supports fundamental research into the epigenetic regulation of genomic stability in beta-cell homeostasis. The project...
- Federal Project Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $840,198 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 21, 2025, with completion targeted for April 30, 2029. The award funds basic biomedical research aimed at understanding cellular and biochemical pathways of adipose metabolism and thermogenesis,...
- Federal Grant Award Summary The Scripps Research Institute received an $801,662 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded on August 15, 2025, with a completion date of June 30, 2029. The research initiative investigates the early initiation phase of Type 1 Diabetes (T1D), a CD4 T cell-mediated autoimmune disease, with specific focus on...
AdventHealth Orlando received a $248,322 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on March 1, 2026, with a completion date of February 28, 2029. The award funds research to identify cell- and spatially-distinct skeletal muscle transcriptional aberrations in insulin resistance and Type 2 Diabetes (T2D). This research addresses a critical gap in understanding how different cell types within skeletal muscle tissue—including myofibers, endothelial cells, immune cells, and fibro-adipogenic progenitors—contribute to insulin resistance at the molecular level. The research deliverables include the development and implementation of advanced transcriptional profiling methodologies using single-cell RNA sequencing via the iCell8 platform and spatial transcriptomics to map dysregulated genes in skeletal muscle tissue at unprecedented resolution. The study integrates physiological assessment tools including hyperinsulinemic euglycemic clamp testing with stable glucose isotope tracers and indirect calorimetry to correlate transcriptional aberrations with insulin-stimulated glucose disposal. These findings are intended to elucidate which specific cell populations and tissue regions drive insulin resistance in T2D, potentially informing future therapeutic targets for the disease, which currently affects over 30 million U.S. adults.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $248.3k | 2/17/26 |