Project Grant R00DE030194
Award Date
6/17/24
Completion Date
5/31/27
Dollars Obligated
$249K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,641,683 in funding to The Trustees of the University of Pennsylvania to conduct research focused on understanding the mechanisms by which human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) become resistant to current radiation and cisplatin therapies. The goal of the research is to...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,743,816 to the Regents of the University of Michigan to study the role of human papillomavirus (HPV) integration structures in driving molecular heterogeneity and tumor progression in HPV-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). The research aims to: 1) Determine the accuracy of using...
This $329,737 Project Grant awarded on September 12, 2023 by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is supporting the development of a rapid, easy-to-use diagnostic platform for the point-of-care detection of high-risk HPV in saliva. The grantee, Innotech Precision Medicine, Inc., is working to create an innovative electrochemical biosensor that combines CRISPR-Cas12 technology with their...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,657,748 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to Case Western Reserve University (CWRU) on July 15, 2024. This grant supports research to determine the mechanisms by which the lead molecule OHM1 reactivates the p53 tumor suppressor and p300 proteins, thereby disrupting the HPV E6 protein's ability to inactivate them. The research aims to (1) understand how OHM1 modulates the p53...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $118,763 to the University of Arizona to assess the transformative versus productive infection of human papillomavirus type 16 (HPV16) in oral epithelial tissues. The research aims to characterize the role of the host transcription factor PPARA in regulating HPV16 productivity and tumorigenicity within distinct...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $109,548 to investigate the evolution of pro-tumoral myeloid cells during the progression from oral epithelial dysplasia to head and neck squamous cell carcinoma. The goal is to develop pharmacological and genetic strategies to intercept the development of these immunosuppressive myeloid cells, which could lead to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $533,707 to conduct research on how the human papillomavirus (HPV) regulates the Hippo signaling pathway. The goal is to elucidate the mechanism by which the HPV E7 oncoprotein activates the YAP1 oncoprotein by degrading the PTPN14 protein, which normally promotes epithelial cell differentiation. The research...
This $701,699 federal Project Grant award from the National Institute of Dental and Craniofacial Research (CFDA 93.121 - Oral Diseases and Disorders Research) aims to advance understanding of the hybrid epithelial/mesenchymal (HEM) state and its impact on immune infiltration in head and neck squamous cell carcinoma (HNSCC). The primary awardee, The General Hospital Corporation (Massachusetts General Hospital), will utilize advanced imaging approaches to develop imaging-based biomarkers related...
The National Cancer Institute (NCI) awarded a $578,249 Project Grant under the Cancer Biology Research (CFDA 93.396) federal grant program to Albert Einstein College of Medicine for the project "Dissecting Tumor-Immune Interactions in HIV-HPV Co-Infection-Associated Oropharyngeal Cancer Using Single Cell Sequencing and Novel Mouse Models." This 5-year project aims to enhance the understanding of how HIV co-infection impacts immune responses and immune evasion in oropharyngeal cancer...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $149,322 to Boston University Medical Campus to investigate novel factors driving the evolution of oral squamous cell carcinoma (OSCC). The research aims to elucidate how aberrant Wnt/β-catenin signaling and associated epigenetic changes, including the role of the histone methyltransferase MLL1, contribute to OSCC...