Project Grant R00AA031718
- Federal Grant Award Summary The University of Tennessee Health Science Center received a $188,313 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded September 26, 2025, with completion targeted for August 31, 2027. The research project evaluates the synergistic effects of developmental and adult alcohol exposure on Alzheimer's disease-related phenotypes using a two-hit model approach. The study investigates...
- Federal Grant Award Summary The University of Tennessee Health Science Center received a $399,076 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded September 15, 2025, with completion targeted for August 31, 2027. The project delivers a rapid and reliable screening platform for identifying and repurposing FDA-approved drugs to treat alcohol use disorder (AUD) and associated comorbidities. The research...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of Tennessee Health Science Center a Project Grant totaling $2,365,880 (awarded September 25, 2025, with completion targeted for August 31, 2029) under the Alcohol Research Programs (CFDA 93.273) to conduct preclinical research examining the neurobiological basis of social context's influence on alcohol self-administration behavior. The research will develop and utilize an...
- Federal Grant Award Summary The University of Tennessee Health Science Center received a $404,250 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 23, 2025, with completion targeted for August 31, 2027. This research project investigates the role of margaric acid in mitigating alcohol-associated liver disease (AALD), a condition accounting for over 5% of global health problems. The...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $453,085 under the Alcohol Research Programs (CFDA 93.273) to The Research Foundation for the State University of New York on September 20, 2025, for a proof-of-concept study examining emotion regulation (ER) dimensions in posttraumatic stress disorder (PTSD)-related drinking risk. The project, which extends through August 31, 2027, addresses a critical gap in understanding how individuals with...
- Federal Grant Award Summary East Tennessee State University received a $249,000 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 23, 2025, with a completion date of August 31, 2028. The project focuses on characterizing acetaldehyde-protein adducts in alcohol-associated liver disease (ALD), specifically investigating how albumin modulates the distribution of acetaldehyde-protein...
- Federal Grant Award Summary Louisiana State University received a $1.19 million Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded August 15, 2025, with completion targeted for April 30, 2030. The research project investigates epigenetic regulation of stress-potentiated ethanol drinking, specifically examining how G9A, a histone methyltransferase, regulates alcohol use disorder through molecular and...
- Federal Grant Award Summary Vanderbilt University received a $156,444 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded January 25, 2026, with completion targeted for July 31, 2028. The award supports fundamental neuroscience research investigating cell-type specific neural mechanisms underlying alcohol-associated behavior and cue-induced alcohol seeking. Specifically, the research elucidates how...
- Federal Grant Award Summary Syracuse University received a $406,857 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) awarded on September 18, 2025, with completion scheduled for August 31, 2027. The research initiative investigates paradoxical alcohol effects on trauma processing in individuals with comorbid Post-Traumatic Stress Disorder (PTSD) and alcohol use. The project challenges prevailing theoretical models...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) awarded $551,464 to the Palo Alto Veterans Institute for Research on September 20, 2025, to conduct a mechanistic research study examining the efficacy of deep transcranial magnetic stimulation (DTMS) as a neuromodulation intervention for alcohol use disorder (AUD). The research will deliver a randomized, double-blind, sham-controlled clinical trial...
The University of Tennessee Health Science Center received a $249,000 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective March 10, 2026 through February 28, 2029. This research initiative investigates the role of somatostatin signaling in the extended amygdala as a potential therapeutic target for comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder (PTSD/AUD). The project applies a multidisciplinary research methodology including in situ hybridization, ex vivo electrophysiology, chemogenetics, viral gene transfer, and behavioral pharmacology to examine how somatostatin may counteract stress-related neuropeptide systems in brain regions critical to both stress regulation and alcohol consumption. The research addresses a significant public health burden by elucidating molecular mechanisms underlying the frequent comorbidity of PTSD and AUD, with the ultimate objective of advancing novel therapeutic development. By examining the central amygdala and bed nucleus stria terminalis, the project seeks to identify how enhanced somatostatin signaling may reduce key PTSD/AUD phenotypes including problematic alcohol consumption, anxiety, sleep disturbances, and other associated symptoms. The award includes a K99 mentoring phase providing the investigator specialized training in advanced neuroscience techniques to support career development and independent research capability.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 4/16/26 | ||
| Not listed | $249.0k | 3/30/26 |