Project Grant R00AA031328
Award Date 9/15/25
Completion Date 8/31/28
Dollars Obligated $249K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
Similar Awards
- This federal Project Grant award of $3,182,397.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to the University of California, San Diego (UCSD). The grant aims to characterize the role of host gut proteases, particularly cathepsin B, and the immune response in alcohol-associated liver disease (ALD) in both a human cohort and a mouse model. The research seeks to determine how alcohol-mediated induction of...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under CFDA 93.273 - Alcohol Research Programs provides $603,499.00 to the University of Texas Health Science Center at Houston (UTHealth) to develop a comprehensive, web-based knowledge module that integrates microbiota, metabolite, and host pathway data to map microbial signatures and mechanisms involved in alcohol-related organ damage (AROD). The project aims to define "alcohol enterotypes"...
- The Project Grant award of $131,654 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) is funding the development of a Lactobacillus-vectored alkaline phosphatase (AP) to mitigate alcohol-induced leaky gut and lipopolysaccharide (LPS) endotoxin load in the gut. The project aims to apply a two-pronged approach using: 1) Lactobacillus-based drug delivery technology to prevent alcohol-induced gut leakiness, and 2) the delivery of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $601,129 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The project, titled "Alcohol and Gut-Brain Axis and the Role of Butyrate on Neuroinflammation and Pain Sensitivity", aims to investigate the relationship between alcohol use disorder, chronic pain, and the gut microbiome, with a focus on the role of...
- The University of California, San Diego (UCSD) was awarded a $414,750 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to investigate the role of intestinal gp130 signaling in preventing alcohol-associated liver disease. The proposed research aims to define the gp130-STAT3-Reg3 signaling axis involved in protecting against ethanol-induced liver disease and assess the potential of a novel engineered gp130...
- This federal Project Grant award of $701,051 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The grant supports research to investigate the phenotypes and functions of distinct neutrophil populations in patients with severe alcohol-associated hepatitis (AH). Key objectives include: 1) Characterizing the transcriptomic profiles and functional roles of neutrophil subsets in AH using single-cell RNA sequencing; 2)...
- This $634,829 Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports a research project titled "Geroprotective Precision Medicine Strategies in PWH that Use Alcohol". The project aims to identify personalized approaches to overcoming inconsistent responses to microbiota-targeted interventions and validate their capacity to offset mechanisms of biological aging in people with...
- The federal Project Grant award of $617,748 was provided by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs) to Cedars-Sinai Medical Center in California. The grant supports research to examine the role of the protein prohibitin 1 (PHB1) in the sensitizing effect of ethanol on colorectal liver metastasis. Specifically, the research aims to investigate how ethanol depletion of nuclear and cytosolic PHB1 in hepatocytes promotes increased expression...
- This Project Grant award, valued at $2,250,249.00 and funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports a research project conducted by the University of California, San Diego (UCSD) to investigate brain features associated with alcohol use disorder (AUD). The project aims to employ longitudinal multi-parametric magnetic resonance imaging (MRI) to assess baseline brain characteristics and changes following alcohol...
- This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs), supports research to determine the molecular mechanism by which the neutrophilic NCF1 gene and its downstream target miR-223 impact the pathogenesis of alcohol-associated liver disease (ALD). The $249,000 project, awarded to the Trustees of Indiana University, will investigate how neutrophils drive disease severity and mediate liver injury in ALD through the...