Project Grant R00AA031313
- This Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs), aims to identify molecular mechanisms that could lead to new treatments for Alcohol Use Disorder (AUD). The $146,816 award to the University of Texas Health Science Center at San Antonio will support research to determine if astrocytic FOLH1 contributes to neuronal hyperexcitability during alcohol withdrawal, and to identify additional genes and pathways in...
- This $249,000 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) aims to investigate the role of the TARP G-8 protein in regulating AMPA receptor-mediated transmission in key brain regions during dependence-escalated alcohol self-administration. The project, titled "Pathological AMPA Receptor Adaptations Governing Dependence-Escalated Alcohol Self-Administration," will be conducted by researchers at Loyola...
- This Project Grant award in the amount of $404,508.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award aims to examine interleukin-1β (IL-1β) synaptic regulation and its role in cognitive impairment during early withdrawal and protracted abstinence from chronic alcohol exposure in male and female mice. The overarching goal is to determine the neuroimmune mechanisms by which chronic...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- The Project Grant award of $657,156.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research to examine the role of BK channels in alcohol-induced dysmyelination. The project aims to investigate the structural and functional correlates of myelin protein changes in a mouse model of alcohol use disorder, focusing on the effects of alcohol on oligodendrogenesis and pre-existing myelin. Key objectives include using...
- This Project Grant award of $123,045.00 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research on the role of the TRAF3IP2 protein in the development of alcohol-related cardiomyopathy. The project will investigate whether alcohol-induced cardiac fibroblast activation, proinflammatory cytokine expression, and extracellular matrix changes are dependent on TRAF3IP2, and whether deleting the TRAF3IP2 gene prevents alcohol-induced...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to investigate the role of cell-type specific gene regulatory networks in alcohol dependence and escalation. The $149,875 award to the University of Texas at Austin will fund a research project with the following key objectives: Assess the impact of genetically rescuing an astrocytic gene co-expression module upregulated in...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $248,844 to the University of North Carolina at Chapel Hill (UNC-CH) for research on the use of blood-based RNA biomarkers to diagnose and monitor Alcohol Use Disorder (AUD). The research aims to determine whether blood gene expression profiles can serve as a non-invasive proxy for brain tissue to aid in personalized medicine approaches...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $152,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Des Moines University Osteopathic Medical Center (DMU) to study the role of GLUD1 receptors in regulating structural plasticity during chronic ethanol exposure and withdrawal. The two-year grant, awarded on September 1, 2023, will support DMU's research aimed at understanding how GLUD1 receptor function and expression influence dendritic spine...
This Project Grant award for $248,997 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) aims to investigate the molecular mechanisms by which chronic alcohol exposure and withdrawal alters RNA splicing, with a focus on the splicing factor PCBP1. The principal investigator, Dr. Luana Carvalho, will manipulate PCBP1 expression using viral-mediated gene delivery to assess its behavioral relevance during alcohol withdrawal and study its effects on the mis-splicing of the HAPLN2 gene, an important regulator of neuronal conductivity. The research will provide insights into how alcohol-induced changes in RNA splicing may contribute to the emergence of negative affective states like anxiety and depression during alcohol withdrawal. The award has a project period from September 16, 2025 to August 31, 2028 and will be performed at Loyola University of Chicago's Health Sciences Campus.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 9/16/25 |