The University of Texas Health Science Center at San Antonio (UTHSCSA) received a $146,816 Project Grant award on February 1, 2025 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award supports research aimed at identifying molecular mechanisms by which chronic alcohol exposure causes neuronal hyperexcitability during alcohol withdrawal. The key products and services to be delivered include:
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Determining if the astrocytic enzyme FOLH1 contributes to neuronal hyperexcitability during alcohol withdrawal using a novel in vitro astrocyte cell culture model.
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Identifying additional alcohol-responsive genes and pathways in astrocytes that may contribute to neuronal hyperexcitability associated with alcohol withdrawal, by analyzing differential gene expression and co-expression networks.
The research is expected to provide new insights into how astrocytes mediate the effects of chronic alcohol exposure on neuronal function, with the potential to identify novel therapeutic targets for the treatment of alcohol use disorder.
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