Project Grant P30GM159569
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,685 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). The funding will support the development of an injectable hydrogel with an integrated urokinase plasminogen activator (uPA) motif and plasmid DNA (pDNA) platelet-derived growth factor B (PDGFB)-lipoplexes to be loaded into the...
- This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
- The University of New Mexico (UNM) Center for Brain Recovery and Repair received a $1,143,750 project grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funding is being used to expand UNM's interdisciplinary research program focused on acquired brain injuries, including stroke and traumatic brain injury. Key activities include recruiting new faculty, renovating research spaces,...
- This federal Project Grant award, valued at $492,749.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS), supports the development of a novel non-invasive magnetic resonance imaging (MRI) technique called ratiometric dual contrast (RDUAL) pH-weighted MRI. The goal is to create an imaging tool that can accurately map the ischemic penumbra (tissue at risk of infarction) and evaluate the risk of reperfusion injury in acute ischemic stroke patients. This research,...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $671,988 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Winifred Masterson Burke Medical Research Institute, Inc. The project focuses on understanding the cross-talk between two cell death pathways, sarmoptosis and ferroptosis, in the context of intracerebral hemorrhage (ICH), a type of stroke. The research aims to explore how the accumulation...
- This federal Project Grant award of $770,502.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling and its role in cerebral small vessel disease (CSVD). The research will use mouse models to perform intravital imaging of the cerebral vasculature and...
- This $540,236 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is funding research to target the RNA regulator HuR in order to suppress inflammation and promote neuroprotection in acute ischemic stroke. The University of Alabama at Birmingham is the primary awardee and will conduct preclinical studies to investigate the...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $407,044 Project Grant to the West Virginia University Research Corporation (WVURC). This grant, effective from August 1, 2025 to May 31, 2030, supports research to characterize the molecular mechanisms by which two proteins, SCFD1 and Synaptotagmin 7, regulate the fusion of autophagosomes with lysosomes. This process is critical for maintaining...
- The National Institute on Aging awarded $3,391,684 under the Aging Research grant program (CFDA 93.866) to Texas A&M University Health Science Center from May 1, 2022 to April 30, 2025. The project aims to test the hypothesis that peripheral insulin-like growth factor-1 (IGF-1), delivered intraperitoneally or orally, will improve acute stroke disability as well as chronic depressive-like behaviors and cognitive impairment post-stroke in a rodent model. Researchers also expect peripheral...
This $1,147,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports stroke research at West Virginia University (WVU). The grant funds the WVU Stroke COBRE (Center of Biomedical Research Excellence) to conduct foundational research on stroke risk factors, neuronal damage mechanisms, novel therapeutics, and strategies to stimulate post-stroke recovery. Key services provided include the Rodent Experimental Stroke and Surgery (RESS) Core, which performs over 3,000 procedures annually, and the Rodent Behavior Core (RBC), which supports advanced 2-photon microscopy capabilities to monitor and manipulate individual neurons during behavioral tasks. The grant will fund this work from September 2025 through July 2030, building on the success of Phases I and II of the WVU Stroke COBRE in training 16 research project leaders, 11 of whom have secured independent research funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 8/27/25 |