Project Grant P01HL173579

Award Date 5/15/25
Completion Date 4/30/30
Dollars Obligated $2.4M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Missouri, USA
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This $2,363,224 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support a comprehensive research program focused on advancing the scientific understanding of von Willebrand factor (VWF) and von Willebrand disease (VWD).

The funded program consists of 4 research projects and 3 supporting cores that will leverage extensive genomic, transcriptomic, proteomic, and clinical data from a large cohort of over 7,000 individuals to:

  1. Identify genetic factors influencing VWF levels and VWD pathogenesis
  2. Generate molecular signatures and polygenic risk scores for low VWF and VWD
  3. Investigate the relationship between VWF and Factor VIII expression, clearance, and immunogenicity
  4. Characterize the role of VWF glycans in its biosynthesis, activation, and clearance

The award will be administered by the Washington University in St. Louis, which has significant expertise in federal biomedical research contracts and grants. Project collaborators include researchers at multiple institutions across the United States.

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