Project Grant P01HL167668

Award Date 8/1/24
Completion Date 7/31/29
Dollars Obligated $5.2M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Milwaukee, WI 53226, USA
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The award supports three interdependent research projects: (1) examining the immunobiology of fetal/neonatal alloimmune thrombocytopenia (FNAIT), (2) investigating the immunobiology of heparin-induced thrombocytopenia (HIT), and (3) exploring the immunobiology of vaccine-induced thrombotic thrombocytopenia (VITT). The research aims to enhance the understanding of molecular and cellular mechanisms underlying these immune-mediated thrombocytopenias, with the goal of developing novel diagnostic and therapeutic applications.

As part of the award, the Children's Hospital of Philadelphia (CHOP) received a sub-award to carry out studies on the VITT project, including defining antibodies that bind to platelet basic protein isoforms and characterizing any detected anti-platelet factor 4 and anti-platelet basic protein antibodies using a mouse model.

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