Project Grant P01AI197186
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $427,625 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 1, 2025, through July 31, 2027. The grant supports research to identify and develop novel anti-biofilm therapeutic agents by exploiting bacteriophage mechanisms that penetrate bacterial biofilm matrices. The research focuses on mining...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Washington University a $427,625 Project Grant on June 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project, scheduled for completion by May 31, 2028, focuses on investigating a broad host-range bacteriophage designated STAB3 and its novel glycan receptor (PGR) as potential therapeutic agents against antibiotic-resistant Acinetobacter...
- Federal Grant Award Summary Award: Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) Funding Amount and Timeline: $254,250 obligated for the period July 1, 2026 through June 30, 2028 Products and Services: This two-year research project, conducted by New York University School of Medicine, focuses on investigating the epigenetic mechanisms and evolutionary generality of bacterial...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Washington University a Project Grant totaling $638,220 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026, through March 31, 2031. This research initiative focuses on DNA ADP-ribosylation mechanisms in bacterial-phage interactions, specifically investigating how bacteria deploy DNA ADP-ribosyltransferase (DART) toxins as anti-phage defense...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Washington University a Project Grant of $664,076 under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026, through March 31, 2031. This five-year award funds research to elucidate the molecular mechanisms by which Staphylococcus aureus alpha-toxin (HLA) impairs antigen-specific T cell responses and adaptive immunity. The research integrates human...
- Federal Grant Award Summary Award Overview The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts a $2.64 million Project Grant on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antimicrobial polymer therapeutics for treating multidrug-resistant (MDR) wound biofilm infections. The four-year award, scheduled for completion on March 31, 2030, integrates synthetic chemistry, computational...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $233,250 under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2027. This award funds research to optimize culturomic and metagenomic methods for detecting multi-strain Clostridioides difficile (CD) colonization and infection. The project addresses a critical gap in current...
- Federal Grant Award Summary Princeton University's Office of Research and Project Administration received a $451,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 23, 2025, with completion targeted for June 30, 2027. The research initiative employs chemical synthetic lethality methodology to identify novel antimicrobial targets in gram-negative bacterial...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Illinois a Project Grant of $440,908 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop inhibitors of bacterial peptidyl-tRNA hydrolase (PTH), an essential enzyme in bacterial protein synthesis. The research deliverables include synthesis and optimization of PTH inhibitor derivatives with enhanced potency against...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Washington University a $179,114 Project Grant (CFDA 93.855 – Allergy and Infectious Diseases Research) effective November 1, 2025, with completion targeted for December 31, 2027. The research develops a high-throughput single-cell RNA-sequencing (scRNA-seq) methodology to identify bacteriophage-host pairs in complex microbial communities. This work addresses a critical gap in phage research:...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Washington University a $1.5 million Project Grant on June 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antibiotic-sparing therapeutic strategies for treating multidrug-resistant (MDR) bacterial infections. The research program, scheduled for completion by April 30, 2031, addresses the critical public health threat posed by antibiotic-resistant pathogens including carbapenem-resistant Enterobacterales, extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales, carbapenem-resistant Acinetobacter baumannii, MDR Pseudomonas aeruginosa, drug-resistant Neisseria gonorrhoeae, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), drug-resistant Streptococcus pneumoniae, and Clostridioides difficile. The funded research integrates expertise in bacterial pathogenesis, virulence factor characterization, artificial intelligence (AI), protein design, multi-omics analyses, and medicinal chemistry to deliver two primary products: (1) transformative antibiotic-sparing therapies that block host-pathogen interactions using revolutionary AI and protein design technologies, and (2) analysis of microbe-treatment interactions to advance therapeutic development for MDR infections. The program comprises three scientific projects and one scientific core designed to revolutionize treatment approaches for important resistant bacterial infections, shifting away from traditional antibiotic-dependent strategies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 6/25/26 |