This $639,485 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the mechanisms of STAT1 and STAT3 activation and nuclear translocation in immune cell signaling. The research aims to decipher how activated STAT1 and STAT3 enter the cell nucleus and how gain-of-function mutations in these transcription factors impact their nuclear signaling and contribute...
This $785,511 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research by the University of Chicago to develop and evaluate induced pluripotent stem cell (iPSC)-derived macrophages as a model to study the genetic basis of inter-individual variation in immune responses to pathogens. The 5-year project aims to provide critical insights into how genetic factors influence individual...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $649,053 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Washington University in St. Louis to investigate the role of Ly49 family receptors on CD8 T cells. The research aims to determine how Ly49 and the transcription factor Helios contribute to the development and function of CD8 regulatory T cells, which have been shown to suppress self-reactive CD4 T cells in autoimmune diseases. This...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,380,350 Cooperative Agreement under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University for the project "Mechanisms of Immune Protection Against Respiratory Viruses". The funding supports a comprehensive research plan with two main goals: (A) defining the mechanisms of germinal center persistence and generation of long-lived memory B cells and plasma cells after...
This $995,244 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 (Allergy and Infectious Diseases Research) aims to determine whether genetic mutations in the transcription factor ASCL1 contribute to the development of organ-specific autoimmunity. The project will investigate ASCL1's role in the function of medullary thymic epithelial cells, which are critical for establishing central tolerance and preventing autoimmunity. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $226,253 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The award supports research to mechanistically understand how the host protein ADAM10 modulates interactions between neutrophils and the endothelium in the context of Staphylococcus aureus infection. The research aims to generate a spatiotemporal analysis of these cellular...
This Project Grant award, valued at $187,398, was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the role of Programmed Death Ligand-1 (PD-L1) and CD80 in regulating dendritic cell migration and T cell priming. Specifically, the research aims to: 1) Define the extracellular interactions between PD-L1 and CD80 that govern dendritic cell migration, and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund a research project to investigate the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis. The $479,249 grant, awarded on January 24, 2025, supports research conducted by The Washington University in Missouri to understand how neutrophil A20 signaling contributes to organ damage in sepsis....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $197,366 to The Washington University in St. Louis to conduct research on understanding the mechanisms of immune-mediated restriction of a specific HIV viral subtype. The key objectives of the 5-year research study are to: (1) characterize the molecular mechanisms driving the natural immune restriction of X4-tropic HIV...
This federal Project Grant award of $2,488,687, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the impact of gammaherpesvirus latency on host immune responses to subsequent pulmonary infections. The award aims to fill key knowledge gaps by 1) examining how gammaherpesvirus latency affects immune cell function during secondary respiratory infections, and 2)...
This federal Project Grant award, valued at $2,483,910.00 and granted by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research into "Novel Mechanisms of Genetic Errors of Immunity." The key objectives of this multi-year, integrated research project are to: 1) investigate epigenetic mechanisms, including autosomal random monoallelic expression, that may contribute to variable disease penetrance and expressivity in primary immune regulation disorders; 2) explore the role of somatic mutations as a cause of genetic errors of immunity; and 3) examine known genetic risk variants and polygenic risk scores that may function as disease modifiers. This award will fund a comprehensive research effort involving an administrative core, a sequencing and sample core, and a bioinformatics core to advance the understanding of these novel disease mechanisms. The research will be conducted by the Washington University, a prominent private research institution located in St. Louis, Missouri.