Project Grant NNX17AJ77G
- Federal Cooperative Agreement Summary The National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded a $6,366,376 Cooperative Agreement to The Leland Stanford Junior University on August 1, 2025, for research assessing the effects of microgravity on cardiovascular aging using artificial intelligence and three-dimensional organoids. The project will develop vascularized cardiac organoids (VCOs)—engineered heart-like tissues containing both cardiac and blood vessel cells...
- This $400,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), under CFDA 47.041 Engineering program, will fund The Johns Hopkins University to develop engineered heart tissue chips for testing nanoparticle-based countermeasures against spaceflight-induced heart disease. The research aims to investigate whether nanoparticles designed to scavenge reactive oxygen species can prevent mitochondrial...
- This $449,582 National Science Foundation project grant funds research at Virginia Polytechnic Institute and State University from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to understand the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, structural changes in capillary network formation...
- The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
- Summary of Federal Cooperative Agreement Award Under a Cooperative Agreement awarded by the National Center for Advancing Translational Sciences (NCATS) through the NCATS Federal Grant Program (CFDA 93.350), Brigham & Women's Hospital Inc. received $3.5 million to develop an advanced three-dimensional (3D) human alveolar lung model in microgravity conditions aboard the International Space Station. The award, effective September 30, 2025, through August 31, 2028, leverages the unique...
- Federal Cooperative Agreement Summary Cedars-Sinai Medical Center received a $1.39 million Cooperative Agreement from the National Center for Advancing Translational Sciences under the Aging Research program (CFDA 93.866) to develop microphysiological systems (MPS), also known as organ-on-chips, for modeling spaceflight-induced accelerated aging and inflammaging in heart, gut, and brain tissues. The award, effective August 15, 2025, through July 31, 2030, supports a two-phase research initiative...
- This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
- This federal Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports a research project at Temple University to investigate how microgravity and radiation exposure impact the function of engineered human adipose (fat) tissue. The $399,994 award, with a performance period from December 2024 to November 2027, will involve sending engineered adipose tissue samples to the International Space Station (ISS) for a 6-month study. The...
- This $382,124 federal Project Grant award, made by the National Science Foundation's Engineering program (CFDA 47.041), aims to advance tissue engineering and in-space cell technologies for regenerative medicine applications. The award will fund a collaborative effort between Micro-Grx, Inc., the University of Florida, Ronawk, and Redwire to develop three-dimensional "bio-block" tissue models that mimic the vascularization of heart and skin cells. These bio-block organoids will be used...
- Summary Wayne State University received a $385,517 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded August 15, 2025, with completion targeted for July 31, 2027. The project focuses on validating a novel wearable device called TRACE that measures orthostatic vital signs through an earlobe-based platform. The research aims to validate TRACE's four orthostatic metrics against transcranial Doppler (TCD) ultrasound—the gold standard for...
LONG DURATION SPACE EXPLORATION MISSIONS CAUSE ASTRONAUTS TO EXPERIENCE PHYSIOLOGICAL DECONDITIONING INCLUDING BONE LOSS MUSCLE ATROPHY CARDIOVASCULAR DECONDITIONING SENSORIMOTOR/BALANCE IMPAIRMENT AND VISION CHANGES. FOR A CREWED MARS MISSION WHERE MICROGRAVITY AND REDUCED GRAVITY (E.G. 0.38 G ON THE MARTIAN SURFACE) EXPOSURE MAY OCCUR FOR 2+ YEARS DECONDITIONING IMPACTS THE ASTRONAUTS HEALTH WELL-BEING EFFECTIVENESS AND SAFETY. HERE WE PROPOSE A NOVEL LINEAR ARTIFICIAL GRAVITY (AG) TECHNOLOGY DESIGNED TO COUNTERACT THESE DELETERIOUS EFFECTS ON THE ASTRONAUTS. PREVIOUS CENTRIFUGE AG SYSTEMS HAVE NEGATIVE IMPACTS DUE TO THE CONSTANT ROTATING ENVIRONMENT: 1) CORIOLIS FORCES WHICH MAY BE CONFUSING AND LIMIT CONCURRENT EXERCISE OR LEAD TO INJURY 2) VESTIBULAR CROSSCOUPLING ILLUSIONS WHICH ARE HIGHLY PROVOCATIVE AND CAUSE MOTION SICKNESS AND 3) GRAVITY GRADIENTS WHERE THE LOADING VARYING ALONG THE LENGTH OF THE ASTRONAUTS BODY. ALTERNATIVELY OUR LINEAR AG TECHNOLOGY (TERMED TURBOLIFT ) SUFFERS FROM NONE OF THESE CONFOUNDING PROBLEMS PARTICULARLY DURING THE ACCELERATION/DECELERATION LOADING PHASES. BRIEFLY THE CONCEPTUAL PARADIGM IS AS FOLLOWS: THE ASTRONAUT IS LINEARLY ACCELERATED AT 1G FOR ~1S THEN IS ROTATED 180 DEGREES TO PREPARE FOR A 1G DECELERATION FOR ~1S. THIS PROCESS IS REPEATED TO CREATE INTERMITTENT AG WHERE THE FORCE IS ALWAYS HEADWARD SIMILAR TO STANDING HERE ON EARTH. THE EXPERIENCE IS LIKELY TO BE ANALOGOUS TO BOUNCING MILDLY ON A TRAMPOLINE. THE INTERMITTENT LOADING IS INTENDED TO REDUCE OR ELIMINATE THE PHYSIOLOGICAL DECONDITIONING IN A COMPREHENSIVE MULTI-SYSTEM MANNER. TO EVALUATE THE LINEAR AG TECHNOLOGY WE AIM TO PERFORM AN ENGINEERING DESIGN ANALYSIS TO QUANTIFY THE REQUIRED SIZE AND MASS OF THE SYSTEM. WE ALSO AIM TO DESIGN A SCALE MODEL OF THE SYSTEM TO TEST ITS FEASIBILITY SUCH THAT IT CAN BE PROPERLY EVALUATED AS COUNTERMEASURE SYSTEM TO ENABLE LONG DURATION CREWED EXPLORATION MISSIONS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| 1 | Funding Only Action | ($28k) | 10/13/17 | |
| Not listed | ($28k) | 10/13/17 | ||
| Not listed | Not listed | $124.6k | 6/7/17 | |
| Not listed | $124.6k | 6/7/17 |