This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
This $400,000 National Science Foundation project grant supports research at Tufts University aimed at understanding the impact of aging on wound healing processes. Specifically, the grant funds two years of research to determine the effects of microgravity on fibroblast phenotype and wound healing response across tissue types and developmental ages. Investigators will leverage the unique environment of the International Space Station to simulate aging processes and their influence on tissue...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
This National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation Project Grant, awarded under CFDA Program 47.041 - Engineering, will provide $399,975 from September 1, 2023 to August 31, 2026 to Colorado State University to conduct research on the effects of microgravity and mechanical deconditioning on tissues. The research aims to investigate how mechanical unloading and microgravity trigger changes in cell nuclei and gene expression, and to develop...
This $1,017,602 National Science Foundation project grant supports research at North Carolina State University to develop microphysiological models for evaluating the role of age-dependent fibrinogen sialylation in wound healing. The three-year award under the NSF Engineering program (CFDA 47.041) will fund the creation of innovative tissue engineering techniques and microfluidic systems to study interactions between platelets and fibroblasts during wound healing. Researchers aim to better...
This $382,124 federal Project Grant award, made by the National Science Foundation's Engineering program (CFDA 47.041), aims to advance tissue engineering and in-space cell technologies for regenerative medicine applications. The award will fund a collaborative effort between Micro-Grx, Inc., the University of Florida, Ronawk, and Redwire to develop three-dimensional "bio-block" tissue models that mimic the vascularization of heart and skin cells. These bio-block organoids will be used...
The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
This Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) provided $174,817 to Virginia Polytechnic Institute and State University from September 2021 through August 2023 for research titled "EAGER/COLLABORATIVE RESEARCH: HIGH-THROUGHPUT, AUTONOMOUS REAL-TIME MONITORING OF TISSUE MECHANICAL PROPERTY CHANGE VIA IMPEDIMETRIC SENSOR ARRAYS." The university will develop high-throughput, autonomous sensors to monitor real-time changes in tissue mechanical...
This $400,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), under CFDA 47.041 Engineering program, will fund The Johns Hopkins University to develop engineered heart tissue chips for testing nanoparticle-based countermeasures against spaceflight-induced heart disease. The research aims to investigate whether nanoparticles designed to scavenge reactive oxygen species can prevent mitochondrial...
This $100,000 National Science Foundation project grant supports the development of a novel multi-wavelength spectroscopy technique and portable analyzer to assess tissue health at Texas A&M Engineering Experiment Station in College Station, Texas. The goal is to prevent pressure injuries through early detection by evaluating tissue oxygenation and blood perfusion beneath the skin's surface, which could help hospitals decrease injury rates and costs. The proposed technology may identify...