Project Grant N660010912122

This R21 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $433,950 to the University of California, Davis to study the impact of wildfire smoke exposure on lung injury and disease in pediatric populations. The key objectives are to: 1) Define the contribution of age on the toxicity of wood smoke particles in respiratory and alveolar epithelium, 2) Investigate the effect of early life wood...

Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Leland Stanford Junior University a Project Grant of $761,017 under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through June 30, 2029. This award funds research focused on human pulmonary neuroendocrine (NE) progenitor cells and their roles in lung injury and disease. The research deliverables include the development of foundational anatomical mapping of human neuroendocrine...

The University of Southern California (USC) Department of Contracts and Grants Division received a $413,958 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The purpose of this 1-year award, effective September 22, 2023, is to investigate the role of the protein PUMA in promoting cell death and inflammation in chronic obstructive pulmonary disease (COPD) caused by cigarette smoke exposure. The research aims...

Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $744,880 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Colorado-Denver for research on epimetabolic regulation of macrophage activation during acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The award, initiated September 1, 2025, and extending through May 31, 2029, supports investigator-initiated research designed to delineate how...

This $427,625 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program will support research at the University of North Carolina at Chapel Hill to characterize the pulmonary immune response induced by single and multiple exposures to combustion products from military burn pits. The studies will use a controlled furnace to burn various components found in military burn pits, including plastics,...

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Trustees of Columbia University in the City of New York a Project Grant of $761,262 under the Cardiovascular Diseases Research program (CFDA 93.837), with performance from September 1, 2025 through June 30, 2029. This award funds research aimed at defining the mechanisms by which intravenously administered bone marrow-derived mesenchymal stromal cells (BMSCs) protect against acute lung injury (ALI). The...

This three-year, $500,000 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Vermont to define environmental design criteria for directing differentiation of type 1 and type 2 lung alveolar epithelial cells. The University of Colorado-Denver and University of Iowa are sub-awardees on the project. Researchers will utilize novel tissue engineering approaches incorporating hydrogels derived from decellularized...

This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...

The National Institutes of Health (NIH) Office of the Director awarded a $1,395,741 Project Grant to the University of Colorado-Denver under the Trans-NIH Research Support program (CFDA 93.310) for a three-year period beginning September 1, 2025 and concluding August 31, 2028. This award funds research examining mast cell activation as a common mechanism of pulmonary toxicity induced by chemical threat agents of concern to the Department of Homeland Security. The research will deliver...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,659,996.00 to the University of Southern California to conduct research on the NF-KappaB modulator PDLIM2 and its role as an intrinsic checkpoint of alveolar macrophages critical for lung innate immunity, inflammation, and diseases. The research aims to investigate how alveolar macrophages, the primary phagocytes in the lung, are transformed to promote lung...