Project Grant K99NS149278
- Federal Project Grant Award Summary The University of Pennsylvania received a $1,137,500 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 1, 2025, with completion targeted for May 31, 2030. The grant funds research investigating epigenetic engrams in planarians, specifically examining how memories and learned behaviors can be encoded and potentially transmitted through molecular...
- Federal Project Grant Award Summary The University of Pennsylvania received a $243,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), with performance at the Philadelphia campus from February 11, 2026 through December 31, 2027. This award supports research utilizing single-nucleus RNA sequencing and chromatin accessibility profiling to...
- Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research) effective September 1, 2025 through August 31, 2027. This award supports research investigating the genetic and molecular mechanisms of cellular senescence in the Drosophila brain. The project leverages Drosophila genetics to identify genes that modulate senescence onset and age-associated brain decline, with the objective of generating insights...
- Federal Grant Award Summary The University of Pennsylvania received a $149,190 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 6, 2026, with completion anticipated by December 31, 2028. The award funds research to elucidate the mechanistic role of inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) in synaptic transmission...
- Federal Project Grant Award Summary Pennsylvania State University, operating through Penn State Milton S. Hershey Medical Center, received a $432,802 project grant awarded June 1, 2025, from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year award, with completion scheduled for May 31, 2027, supports cross-validation research of gene expression changes associated...
- Federal Project Grant Summary Drexel University received a $358,313 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 7, 2025, through July 31, 2030. The award supports a five-year research initiative investigating how prior knowledge shapes the consolidation and long-term storage of new episodic memories. The research employs...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Pennsylvania a Project Grant totaling $2,817,215 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The four-year award, scheduled for completion by July 31, 2029, funds research to elucidate the role of TRIM10 protein in maintaining TDP-43 (TAR DNA-binding protein 43) solubility and...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $532,314 to the Regents of the University of Michigan on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This Project Grant supports neuroscience research investigating the interplay between sleep pressure, circadian timing, and hippocampal neuronal activity through June 31, 2031. The research involves recording...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Pennsylvania a $446,875 Project Grant effective June 1, 2025, through May 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The research project focuses on generating and characterizing a novel NTRK3-FLPO knockin mouse line to enable genetic interrogation of Aβ nociceptors—a previously inaccessible population of...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pennsylvania a Project Grant totaling $198,164.00, effective December 1, 2025, through May 30, 2028, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award supports fundamental research investigating the pathophysiology of SCN3A-related neurodevelopmental disorder (SCN3A-NDD), a newly identified genetic...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pennsylvania a Project Grant totaling $128,115.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for the period of July 1, 2026 through June 30, 2028. This research initiative, titled "Defining the Mechanisms Underlying Generational Memory Inheritance," investigates how irregular light exposure impairs associative memory across multiple generations through epigenetic mechanisms and germline-to-brain signaling pathways. The funded research employs Drosophila (fruit fly) as a genetically tractable model organism to elucidate the molecular mechanisms by which constant light and chronic jet lag impair memory performance and transmit this impairment to subsequent generations. The project specifically examines the role of the PIWI-interacting RNA (piRNA) pathway and H3K9me3 chromatin marks in dopaminergic neurons, as well as dopamine receptor signaling in memory-relevant neural circuits. The deliverable products include mechanistic insights into epigenetic inheritance of light-induced memory deficits, identification of memory-relevant neural circuits and signaling molecules, and fundamental knowledge applicable to understanding how environmental stressors contribute to neurological disorders across generations. Research will be conducted at the University of Pennsylvania's Philadelphia, Pennsylvania campus.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.1k | 5/25/26 |