Project Grant K99NS149066
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $671,445 to Weill Medical College of Cornell University on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds development of an integrated pipeline for early Parkinson's disease prediction and disease-modifying drug repurposing. The work targets the...
- The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $235,305 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of enteric alpha-synuclein in Parkinson's disease pathophysiology. The research will determine region-specific and temporal changes in alpha-synuclein expression and synaptic vesicle-binding in the enteric nervous system using...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $627,103 to the Research Foundation For Mental Hygiene, Inc. on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The Research Foundation For Mental Hygiene, Inc., operating through its New York State Psychiatric Institute division, will investigate the role of the adaptive...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $566,529 on April 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate age-related deficits in trophic support of dopamine neurons in preclinical models of Parkinson's disease. The research examines cell-type-specific alterations in LRRK2G2019S mice to determine how the LRRK2 mutation affects neuroprotective signaling...
- The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $603,264 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate endothelial sphingolipid signaling in cerebrovascular inflammation and cognitive decline. The project examines how sphingosine-1-phosphate receptor signaling in cerebrovascular endothelial cells regulates blood-brain barrier function...
- The National Institute of Neurological Disorders and Stroke awarded the University of Georgia Research Foundation $1,297,188 on May 8, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neuroinflammatory epitranscriptomic mechanisms in Parkinson's disease. The research examines the role of the ALKBH5 demethylase enzyme in microglial neuroinflammatory responses triggered by alpha-synuclein aggregates, a hallmark...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $670,266 on January 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to map the epigenomic and spatial transcriptomic landscape in Parkinson's disease and Alzheimer's disease. The project characterizes shared and distinct transcriptional changes between Parkinson's disease, Alzheimer's disease, and Alzheimer's...
- The National Institute of Neurological Disorders and Stroke awarded the University of Connecticut Health Center $1.815 million on August 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on the regulation of beta-glucocerebrosidase in Parkinson's disease and related dementias. The research examines how the protein GCIP1 regulates beta-glucocerebrosidase (GCase) processing, trafficking, and maturation in...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $198,164 to Weill Medical College of Cornell University on September 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of heme in oxidative modification of mRNA in neurodegenerative disease. The research examines how heme binds to G-quadruplex sequences...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $452,375 on June 15, 2026, under the Aging Research program (CFDA 93.866) to develop gene therapy targeting non-motor defects in synucleinopathy. The project addresses gastrointestinal dysfunction in Parkinson's disease and related synucleinopathies by investigating alpha-synuclein pathology in the enteric nervous system. The research employs single-chain variable fragments (scFvs)—antibody...
The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $122,850 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of progranulin microglial replacement therapy in Parkinson's disease. The research establishes a therapeutic paradigm using induced pluripotent stem cell–derived microglia that overexpress progranulin and evaluates their functionality in a mouse model of Parkinson's disease. The work tests whether cell-intrinsic neuroprotective properties and secreted progranulin from this microglia replacement therapy reduce neurodegenerative pathology and improve behavioral deficits associated with Parkinson's disease and frontotemporal dementia. The study addresses the retinal-brain pathology link in Parkinson's disease, where visual deficits associated with retinal alpha-synuclein deposits precede brain pathology, and explores the retina as an accessible target to assess and treat neurodegeneration. The award funds research performed at Weill Medical College's New York, New York location. The period of performance runs from September 1, 2026, through August 31, 2028. This is a Project Grant, an assistance type supporting investigator-initiated research through the National Institute of Neurological Disorders and Stroke's extramural research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $122.9k | 8/25/26 |