Project Grant K99HL183751
- Federal Project Grant Summary St. Jude Children's Research Hospital Inc. received a $150,104 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective March 4, 2026, with a completion date of November 30, 2028. The award funds research titled "Decoding Influenza-Induced Damage: What's All the Hyp(oxia) About?" conducted at the hospital's Memphis, Tennessee facility. The project aims to...
- Federal Grant Award Summary St. Jude Children's Research Hospital Inc. received a $277,500 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 1, 2025, with a completion date of July 31, 2027. The project addresses executive functioning impairment in pediatric patients with sickle cell disease (SCD) through a clinical investigation of methylphenidate (MPH) efficacy and safety. Sickle cell...
- Federal Grant Award Summary Boston Children's Hospital received a $267,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion anticipated by July 31, 2027. The award funds research to identify shared molecular mechanisms underlying congenital heart disease (CHD) and neurodevelopmental delay and disability (NDD) by characterizing dysregulated gene expression in...
- Federal Project Grant Award Summary Boston Children's Hospital received a $4.05 million Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion targeted for May 31, 2030. The grant funds "Optimizing HCT Outcomes: A Multi-Omic Investigation," a research initiative focused on improving outcomes for patients undergoing hematopoietic stem cell...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $776,511 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for May 31, 2029. This award supports research to develop and validate a three-dimensional engineered hemogenic vascular niche model designed to elucidate the microenvironmental factors that promote hematopoietic stem...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $865,286 to Boston Children's Hospital (The Children's Hospital Corporation) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of June 30, 2029. This research initiative will produce a high-resolution spatiotemporal lineage map of cardiac development by integrating advanced lineage tracing, spatial, and single-cell...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Children's Hospital of Philadelphia Research Institute a $445,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) for a three-year period from July 15, 2025, through June 30, 2028. This award supports research determining genetic mechanisms that drive in vitro hematopoiesis, specifically investigating how the tropomyosin 1 (TPM1) gene impacts the development of...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $1,175,924 under the Cardiovascular Diseases Research program (CFDA 93.837) effective April 1, 2026, with an ultimate completion date of January 31, 2033. This research grant supports Dr. Sturgeon's investigation into hemogenic mesoderm heterogeneity, regulation, and function—specifically examining the molecular and transcriptional mechanisms by...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $1,326,626 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on May 15, 2025, with a completion date of February 28, 2029. The research project, titled "DLK1 Regulates HSC Quiescence Through Phase Separation Mediated Inhibition of Receptor Signaling," focuses on elucidating the mechanisms by which Delta-like...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Columbia University's Health Sciences Division a $1.14 million Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) beginning April 1, 2026, with completion targeted for January 31, 2033. This award supports fundamental research investigating the dynamics and plasticity of the hematopoietic stem cell (HSC) niche—the specialized microenvironment that regulates blood cell production....
St. Jude Children's Research Hospital Inc. received a $140,809 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded April 10, 2026, with a completion date of March 31, 2028. The award supports comparative vertebrate research investigating neural crest cell (NCC) contribution to hematopoietic stem cell (HSC) specification in the embryonic hematopoietic niche. This research addresses the critical clinical challenge of generating functional HSCs in vitro from induced pluripotent stem cells (iPSCs) to expand the donor pool for bone marrow transplantation in treating hematological and non-hematological disorders. The research deliverables include scientific investigation of developmental signaling mechanisms by which neural crest cells direct HSC specification from hemogenic endothelium in the dorsal aorta, comparing findings across zebrafish and mouse model systems. The project builds on preliminary data demonstrating that neural crest cells migrate to the dorsal aorta during the HSC specification window and deliver inductive signals independent of catecholamine production. By elucidating the specific molecular cues provided by neural crest cells for HSC specification, this research is expected to generate novel insights applicable to improving in vitro HSC generation protocols and advancing therapeutic HSC transplantation capabilities.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $140.8k | 4/8/26 |