Project Grant K99HL181079
- This $165,980 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports a computational analysis of hemodynamics in patients with renal artery fibromuscular dysplasia (FMD). The goal is to investigate the impact of large vessel and small vessel disease on FMD versus atherosclerotic renal artery stenosis (ARAS) patients through hemodynamic indices like fractional flow reserve (FFR) and index of microvascular resistance...
- This $604,301 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Versiti Wisconsin, Inc. will support research on membrane-cytoskeleton interactions in megakaryocytes and platelets. The research aims to advance the understanding of abnormal platelet production and function, which can pose significant clinical risks including bleeding and thrombotic events. The project will investigate the precise molecular mechanisms...
- This $109,812 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on using extracellular vesicles derived from endothelial cells to potentially treat vascular disease in MELAS, a common mitochondrial disorder. The research aims to characterize the mitochondrial content and quality within these extracellular vesicles and assess their ability to ameliorate inflammatory effects in MELAS-affected endothelial cells....
- The National Heart, Lung, and Blood Institute (NHLBI), through its Cardiovascular Diseases Research program (CFDA 93.837), awarded a $779,952 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to investigate the role of platelets in regulating non-neurological complications of ischemic stroke. The 4-year project, running from June 2025 to March 2029, aims to gain a deeper understanding of how activated platelets contribute to remote organ injury and...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
- The Project Grant award of $639,621 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM) to investigate mitochondrial signaling between cardiomyocytes and fibroblasts, and its role in cardiac fibrosis. The research aims to determine how cardiomyocyte-derived mitochondria mediate crosstalk with cardiac fibroblasts, which may underlie the...
- The Case Western Reserve University (CWRU) received a $121,003 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the atomic-level structural and functional characteristics of platelet membrane proteins. The research aims to leverage cutting-edge cryogenic electron microscopy (cryo-EM) techniques, including the Build and Retrieve (BAR) method and cryo-focused ion beam (cryo-FIB) sample preparation, to...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $151,523 to The Medical College of Wisconsin, Inc. to investigate the role of fibrinogen in regulating inflammation and thrombus resolution in acute and chronic venous thrombosis. The research aims to develop a novel RNA therapy using lipid nanoparticles to selectively reduce circulating fibrinogen levels and elucidate its impact on thromboinflammatory processes....
- This $1,332,404 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of basolateral endothelial cilia in promoting vascular stability in the brain. The awardee, The Medical College of Wisconsin, Inc., will investigate the hypothesis that basolateral endothelial cilia facilitate cell-cell communication with pericytes to regulate vascular stability through signaling pathways involving PDGF-BB, heparan...
- The University of Rochester was awarded a $573,261 Project Grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to investigate the role of platelets in regulating monocyte immune responses during vascular inflammation. The 4-year research project, beginning August 1, 2025, aims to understand how resting platelets interact with monocytes to epigenetically "train" their innate immune responses, and how this process is altered by platelet...
This $118,919 project grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to investigate the use of platelets and platelet-derived extracellular vesicles as biomarkers for diagnosing and predicting stroke risk in patients with Fibromuscular Dysplasia (FMD), a vascular disease predominantly affecting women. The key objectives are to: 1) Develop a blood-based diagnostic test for FMD with 95% accuracy, and 2) Characterize the platelet phenotype in an FMD mouse model. This multi-year project (August 2025 to June 2027) leverages access to a large FMD patient cohort at the Cleveland Clinic to advance understanding of this underdiagnosed vascular condition and explore novel approaches for improving patient outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $118.9k | 7/30/25 |