Project Grant K99HL177343
- This federal Project Grant award of $621,546.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), focuses on observing the single molecule dynamics of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) under both normal and disease-associated conditions. The primary objectives are to: 1) Engineer a single-walled carbon nanotube field effect transistor (SWNT FET) system to record PKA-C single molecule...
- This Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $131,571 to Vanderbilt University Medical Center to research methods for improving the trafficking of the KV11.1 potassium channel protein to treat Long QT Syndrome. The project aims to 1) test the drug candidate evacetrapib for its ability to enhance trafficking of KV11.1 variants, and 2) identify protein interactions that could...
- The University of South Florida was awarded a $2,074,842 Project Grant by the National Heart, Lung, and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) to investigate how post-translational modifications of the CaMKII protein during chronic diabetes impact endothelial small-conductance calcium-activated potassium (SK) channel activity, coronary microvascular function, and myocardial blood flow. The overall goal is to expand scientific understanding of the mechanisms underlying...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $733,371 in funding to the University of California, Davis to conduct research on the pressure regulation of vascular Cav1.2 channels. The research aims to advance understanding of the role of vascular smooth muscle Cav1.2 channels in the myogenic response and vascular reactivity, and how these dynamics may be altered in disease states. The award period runs from...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program CFDA 93.837 - Cardiovascular Diseases Research, will support research to define cellular pathways that regulate lipid flux and elucidate their impact on cardiovascular disease. The $773,259 award, with a project period from December 2024 to November 2028, will enable the University of California, Los Angeles (UCLA) to: 1) Identify novel cholesterol-responsive proteins in the...
- This $631,261 Project Grant award from the National Heart Lung and Blood Institute (CFDA Program 93.837 Cardiovascular Diseases Research) supports research at Rutgers University to elucidate the role of autophagy and mitochondrial quality control mechanisms, including mitophagy, in the senescence of cardiomyocytes and the development of cardiomyopathy. The research aims to determine how aging-induced suppression of autophagy promotes senescence in cardiomyocytes, leading to the accumulation of...
- This $153,117 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of the recipient's independent research career as an academic hematopathology physician-scientist. The key objectives are to study hematopoietic stem and progenitor cell (HSPC) crosstalk and transplantation, with the overarching goal of improving HSPC transplantation outcomes. The award period runs from August 1, 2025 to July 31,...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $708,265 in funding to Weill Medical College of Cornell University from September 1, 2025 through June 30, 2029. The research project aims to expand understanding of how fibroblast growth factor homologous factors (FHFs) influence cardiac physiology and how genetic variants contribute to arrhythmias, providing a platform for targeted therapies. Key research objectives...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $331,344.00 to The Leland Stanford Junior University to investigate the gene regulatory mechanisms of the coronary artery disease gene PRDM16 and its impact on smooth muscle cell phenotypic modulation. The research aims to determine how PRDM16, an epigenetic modifier, regulates the transition of smooth muscle cells into protective "fibromyocytes"...
This Project Grant award, provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the regulation of cardiac L-type calcium channel trafficking mediated by ubiquitin and SUMO. The $133,436 award will fund a project led by Principal Investigator Dr. Sri Karthika Shanmugam at Columbia University to conduct mechanistic and functional studies on this topic. The research program will advance Dr. Shanmugam's skills in cardiac contractility experiments, SUMO-based trafficking and functional studies, and other key career development activities to facilitate her transition to an independent academic position. The award period runs from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.4k | 7/31/25 |