Project Grant K99HD118580
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $654,844.00 to the Rector & Visitors of the University of Virginia to study the mechanisms underlying the pathogenesis of SEL1L-HRD1 ERAD disease variants. The research aims to determine the causality and pathophysiological significance of specific human SEL1L and SYVN1 gene variants, as...
- This $140,400 federal Project Grant was awarded on September 1, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to study the functions of lipid homeostasis during neural tube closure, a critical embryonic process for brain and spinal cord development. The research will use the FAF2 knockout mouse model to evaluate how dysregulation of lipid...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to investigate the impact of coding and non-coding mutations in the ARID1B gene on neurodevelopmental disorders (NDDs). The $294,408 award, spanning November 2024 to May 2027, will enable Emory University to characterize ARID1B haploinsufficient mice at the...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $249,000 Project Grant to The Leland Stanford Junior University (Stanford University) on August 1, 2025. The award, funded through the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865), will support a research project titled "Predicting Long-Term Outcomes in Preterm Infants Using Multimodal Neuroimaging Techniques and Environmental Factors." The...
- The University of California, Irvine received a $185,388 project grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on how gene regulatory redundancy ensures robustness of mammalian development. The project aims to identify the distinct transcription factors driving each "shadow enhancer" - redundant regulatory elements that...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $187,500 Project Grant on August 11, 2025 to the Pennington Biomedical Research Center in Louisiana. The grant, titled "BEYOND FOLATE - A SUPPLEMENTATION STRATEGY TO PREVENT NEURAL TUBE DEFECTS", falls under the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to investigate a novel nutritional approach to prevent neural tube...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $595,864 Project Grant to the Magee-Womens Research Institute and Foundation in Pittsburgh, PA, effective August 15, 2025 and scheduled for completion on May 31, 2030. The grant, awarded under the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to elucidate the role of hyaluronan, a key extracellular matrix component, in the development...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to characterize the structural and functional brain development trajectories of offspring with and without prenatal exposure to maternal psychological distress (MPD). The $768,372 award, made on September 4, 2025, will support a longitudinal study to assess the neurodevelopmental...
- This Project Grant award of $248,994 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which administers the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award will fund research by the Washington University in New York, NY to investigate the mechanisms by which histone mutations affect chromatin structure, gene expression, and neural differentiation during development. The goal is to...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on identifying novel noncoding genetic mechanisms that contribute to developmental disorders. The $499,055.48 award, with a project period from November 1, 2024 to October 31, 2027, will fund research led by Dr. Chelsea Lowther at the Icahn School of Medicine at Mount...
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), awarded a $131,166 Project Grant to the Rector & Visitors of the University of Virginia (UVA) to support research on the critical role of the SEL1L-HRD1 endoplasmic reticulum associated protein degradation (ERAD) pathway in neurodevelopment. The research aims to determine how disruption of this ERAD pathway contributes to intellectual disability, microcephaly, developmental delay, and locomotor dysfunction observed in patients with the ERAD-associated neurodevelopmental disorder. Utilizing mouse models and advanced imaging/biochemical techniques, the project will investigate how the SEL1L-HRD1 complex regulates the biogenesis of the neuron migration-related adhesion molecule ASTN1 in the endoplasmic reticulum. The award has an ultimate completion date of July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.2k | 8/8/25 |