This $117,226 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research at the University of North Texas Health Science Center (UNTHSC) to determine the role of gestational hypoxia, a characteristic of gestational sleep apnea, in contributing to maternal neuroinflammation, cognitive deficits, and psychosocial dysfunction during pregnancy and postpartum. The 2-year project aims to use a preclinical rat model to: 1) assess the effects of gestational hypoxia on maternal cognitive and psychosocial function, and 2) evaluate the contribution of maternal hippocampal pro-inflammatory responses to neuronal dysfunction. This research will establish the link between gestational hypoxia-induced inflammation and pregnancy-associated brain health outcomes, with the goal of launching the PI's independent academic career focused on maternal brain health.
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