This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research provides $135,864.00 to the Whitehead Institute for Biomedical Research to conduct research aimed at uncovering the regulatory mechanisms that promote and maintain germ cell identity.
The research program seeks to uncover the molecular mechanisms that initiate and maintain germ cell identity by revealing the primordial germ cell (PGC) gene regulatory network. The key objectives are to discover the dynamics of germline gene activation during embryogenesis, identify PGC-specific cis-regulatory sequences and associated transcriptional regulators, and examine the function of the RNA-binding protein Nanos in promoting the germline program and/or repressing somatic programs. This research will provide fundamental understanding of the mechanisms that specify germ cell fate, promote fertility, and protect the survival of the species. The award period runs from Sep 15, 2024 to Aug 31, 2026.
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