Project Grant K99GM166994
- The National Institute of General Medical Sciences awarded Yale University $125,000 on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the influences of developmental metabolic flux on physicochemical properties of the nucleus. The research focuses on how metabolic changes during cell differentiation alter mechanical properties of the nuclear envelope, with particular attention to polyamine biosynthesis. The investigator will test...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $211,433 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and biophysical principles governing protein-glycan interactions. The research program pursues three major objectives: defining the thermodynamic and structural basis of protein-glycan interactions at the atomic level to reveal how proteins achieve specificity within...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $605,140 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate cellular and molecular mechanisms of lipid-mediated protein trafficking through the mammalian Golgi complex. The research investigates how palmitoylation in the early secretory pathway sorts proteins and accelerates their...
- Federal Grant Award Summary Yale University received a $2.1 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award supports fundamental research investigating the biological role and pharmacology of the EXPERA family of membrane proteins, specifically sigma-2 receptor (TMEM97) and transmembrane 6 superfamily member 2 (TM6SF2),...
- The National Institute of General Medical Sciences awarded Yale University $381,671 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate pyrazin(on)e-associated chemical signaling in pathogenic Klebsiella species and related bacteria. The project characterizes molecular mechanisms by which pyrazine and pyrazinone signaling pathways regulate bacterial metabolism, biofilm formation, and iron metabolism in Klebsiella oxytoca and related...
- The National Institute of General Medical Sciences awarded Yale University $420,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling enzymes, chemistries, and probes for expanded proteomic and lipidomic analysis. The research addresses limitations in current proximity labeling applications, which create localized reactive intermediates to tag nearby proteins in their native cellular environment. Existing...
- The National Institute of General Medical Sciences awarded Yale University $922,854 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop scalable statistical methods for inferring interactions within large biological networks and to apply these methods to neural activity and chromatin structure. The research will leverage recordings of thousands of neurons in the mouse hippocampus and visual system to identify networks of neural interactions...
- The National Institute of General Medical Sciences awarded the University of Connecticut $607,470 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop mass spectrometry-based methods for sequencing large modified RNA molecules. The project, designated R01GM162759, runs through February 28, 2030, with place of performance in Storrs, Connecticut. The funded research aims to remove analytical barriers that have limited adoption of mass...
- The National Institute of General Medical Sciences awarded Yale University $2,014,434 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a synthetic biology tool that engineers proteins with multiple posttranslational modifications and elucidates their binding function. The project addresses the challenge that protein complexes differentiated by posttranslational modifications cannot be separated from non-modified complexes in mammalian...
- Federal Grant Award Summary Yale University received a $2.31 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 8, 2025, with completion targeted for September 7, 2029. The research project, titled "Decoding the Molecular Choreography of Diverse Vesicle Release Mechanisms," will advance fundamental understanding of large dense-core vesicle (LDCV) fusion...
The National Institute of General Medical Sciences awarded Yale University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular and structural basis of glycoRNA-receptor interaction. The project will determine the chemical, biochemical, and structural bases of glycoRNA-P-selectin interactions, establishing this system as a model to dissect the molecular principles and physiological functions of RNA glycosylation. Work comprises two primary aims: defining the biochemical properties and binding characteristics of glycoRNAs-P-selectin interaction by quantifying kinetic parameters and the contributions of RNA and glycan moieties, and determining the chemical composition of P-selectin-binding glycoRNAs to identify both RNA templates and glycan structures. The research will establish glycoRNAs as a new class of extracellular signaling molecules that mediate cell-cell communication, with applications to immunity and inflammation. Performance occurs in New Haven, Connecticut through August 31, 2028. This is a K99/R00 award supporting early-career investigator transition to independence in basic biomedical research funded by NIGMS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/21/26 |