Project Grant K99GM166738
- The National Institute of General Medical Sciences awarded $502,372 to Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop selective, catalytic isomerization reactions that convert simple organic building blocks into complex organic molecules relevant to biomedical research. The work encompasses stereocenter editing—precise interconversion of stereoisomeric molecules at late synthetic stages to enable...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $127,567 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of nuclease-based bacterial immunity systems. The research, carried out in Cambridge, Massachusetts, through August 31, 2028, combines genetic and molecular biology approaches with training in biochemistry, structural biology, and computational methods to dissect how...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $269,071 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply cryo-electron microscopy and cryo-electron tomography methods for visualizing protein machine assembly, function, and regulation at high resolution. The work emphasizes development of the CryoDRGN and TomoDRGN software ecosystem to enable structural analysis of complex samples in...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $150,104 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate stereoselective hydrogen atom abstraction using chiral amine-borane catalysts and develop a deracemization protocol for converting racemic starting materials into high-value enantioenriched products, specifically targeting beta2- and gamma2-amino acids. The research will leverage the...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $655,926 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to design and optimize high refractive index proteins for deep tissue imaging in living biological systems. The research addresses a core limitation in light microscopy: refractive index mismatching between aqueous and lipid fractions of cells causes light scattering that prevents visualization of...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $300,196 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural investigations into the regulatory states of human ribonucleotide reductase using cryogenic electron microscopy. The project uses cryo-EM to determine structures of the human RNR protein in both active and inactive states. The first aim involves determining cryo-EM structures...
- The National Institute of General Medical Sciences awarded Northeastern University $434,000 in Project Grant R35GM162269 on March 2, 2026, to develop integrated mass spectrometry strategies for characterizing metabolite-protein cross-regulation in cellular metabolism. The recipient will apply mass spectrometry-based methods to simultaneously probe metabolites and proteins in the cellular context, bridging a gap in current research that has typically focused on either metabolites or proteins...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $327,085 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2026. The award supports fundamental research to develop innovative chemical and molecular tools for investigating human lectin function and their interactions with glycan structures on cellular surfaces. The...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services, awarded $440,465 to the Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop biophysical models of genome folding and function. Over the five-year performance period ending February 28, 2031, the award funds research into chromosome architecture and the mechanisms that shape it—motor-driven loop...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $125,000 on May 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated computational and experimental platform for decoding, modulating, and designing protein free energy landscapes. The funded research will establish methods for resolving complete protein free energy landscapes and predicting how they respond to...
The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $121,866 on August 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop open-source computational workflows for metabolite structural elucidation in untargeted metabolomics. The project will expand the ICEBERG geometric deep learning model to train on curated open-source datasets (GNPS, MassSpecGym) through knowledge distillation from proprietary models and introduce atom-level confidence scoring. The work will generate interpretable confidence maps for metabolite annotation independent of commercial data. During the independent R00 phase, network-based reasoning incorporating integer-linear optimization and graph-based propagation will enable joint analysis of chemically related spectra to create an open metabolite atlas through pan-repository substructure annotation. Proof-of-principle applications will demonstrate biological relevance in cancer metabolism, inflammatory bowel disease, and mitochondrial disease cohorts. Performance occurs in Cambridge, Massachusetts. The award runs through July 31, 2028. This is a K99/R00 mentored-to-independent transition grant supporting a candidate's progression from mentored research to independent research leadership.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $121.9k | 8/21/26 |