Project Grant K99GM166627
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $211,433 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and biophysical principles governing protein-glycan interactions. The research program pursues three major objectives: defining the thermodynamic and structural basis of protein-glycan interactions at the atomic level to reveal how proteins achieve specificity within...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded $370,550 to the University of California, San Diego on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for development of the Intracellular Protein Organization Landscape (IPOL), a quantitative computational framework that characterizes cell types and states based on spatial protein organization rather than molecular composition. The award funds research integrating high-resolution imaging,...
- The National Institute of General Medical Sciences awarded $124,767 to The Regents of the University of California, San Francisco on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance de novo protein design for catalysis and fluorescence imaging. The research tests the hypothesis that protein dynamics, particularly enrichment of productive conformations, contribute to enhanced catalytic rates in engineered proteins. Prior work under this funding...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $150,104 under the Biomedical Research and Research Training program (CFDA 93.859) on March 1, 2026. The award funds de novo design of artificial haloperoxidase enzymes using machine-learning tools for protein design and structure prediction. The research investigates metalloenzyme structure-function relationships through design of vanadium- and heme-dependent haloperoxidase enzymes that oxidize...
- The National Institute of General Medical Sciences awarded $151,041 to The Regents of the University of California, doing business as University of California, Berkeley, on January 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant. The recipient will design and develop supramolecular hosts that function as photocatalysts to induce novel photochemical reactions that afford access to oxygen- and nitrogen-containing heterocycles in a highly...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $551,000 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop function-selective modulators of multifunctional hub proteins. The research expands two programs: developing molecular glues to stabilize native protein-protein interactions and establishing technologies to study dynamic protein-interaction networks. The work...
The National Institute of General Medical Sciences awarded the University of California, San Diego $125,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop photocatalytic proximity labeling platforms and near-infrared photocaging methods that map protein interactions in lipid-based systems and hydrophobic tag protein degraders. The project, titled "Harnessing Hydrophobic Interactions for Photocaging and Photoproximity Labeling," addresses the largely unexplored use of hydrophobic interactions in catalytic proximity labeling to study lipid-proteomic networks and protein degradation mechanisms in living cells. Aim 1 develops near-infrared-responsive photocaging methods to modulate hydrophobic tag-based protein degradation and lipid signaling. Aim 2 develops near-infrared-activated proximity labeling platforms to comprehensively map lipid-protein interactions, with potential to overcome limitations of conventional diazirine-based photoaffinity labeling and identify new drug targets and lipid-binding proteins. Aim 3 profiles hydrophobic tag degrader interactomes using near-infrared-triggered proximity labeling. Performance occurs in La Jolla, California. The award runs from August 1, 2026, through July 31, 2028, as a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 7/28/26 |