Project Grant K99GM164681
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Columbia University's Health Sciences Division a Project Grant of $287,488 under the Biomedical Research and Research Training program (CFDA 93.859) on July 15, 2025, with a completion date of April 30, 2030. The award supports research focused on mechanism-informed design of allosteric protein sensors. The research program aims to advance understanding of how proteins occupy conformational...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $444,907 to The Trustees of Columbia University in the City of New York on May 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). This Project Grant (R35 mechanism) supports fundamental research aimed at discovering central principles governing cellular adaptation at the systems level. The research encompasses three primary projects: (1) investigating cellular...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $124,767 to The Regents of the University of California, San Francisco under the Biomedical Research and Research Training program (CFDA 93.859) for the period May 1, 2026 through April 30, 2028. The award supports de novo protein design research focused on engineering proteins that bind small molecules and catalyze chemical reactions. The research builds on the investigator's...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $654,950 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Biomedical Research and Research Training program (CFDA 93.859) to establish a unified framework for generating oligonucleotide-based receptors, known as aptamers, for small molecules that are difficult to isolate using standard isolation protocols. The research, which...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Columbia University's Health Sciences Division a $443,878 Project Grant on August 5, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on geometrical regulation of collective cellular responses in three-dimensional space and time. The research investigates how macroscopic tissue geometries—including curvature, concavity, continuity, and aspect...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences awarded a $1,440,905 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) effective September 1, 2025, through August 31, 2029, under the Medical Library Assistance program (CFDA 93.879). This award funds research to develop advanced machine learning models and computational methods for predicting stable and transient protein-protein interactions...
- Project Grant Award Summary The University of Chicago received a $487,525 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through December 31, 2030. The award supports fundamental research to develop evolution-based understanding and design principles for protein engineering through the integration of artificial intelligence (AI) and experimental biology. The...
- Project Grant Award Summary Northwestern University received a $540,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2030. The award supports high-throughput discovery and computational modeling of protein stability and dynamics, leveraging machine learning advances to predict protein folding properties at unprecedented scale. The...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $436,361.00 under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year project (August 1, 2025 – July 31, 2030) focused on advancing protein structure determination methodologies. The Research Foundation for the State University of New York, serving as the fiscal agent for research conducted in Buffalo, will develop innovative computational algorithms and...
- Federal Project Grant Award Summary The University of California, San Francisco received a $501,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 5, 2025, with completion targeted for May 31, 2030. The grant funds fundamental research focused on bridging the gap between predicted and actual protein structures in structural biology, with particular emphasis on understanding...
The National Institute of General Medical Sciences (NIGMS) awarded $125,000 to The Trustees of Columbia University in the City of New York on May 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a research project titled "Decoding and Engineering Free Energy Landscapes for Mechanistic Insight and Functional Protein Design." The award extends through April 30, 2028, and will be conducted at Columbia University's Health Sciences Division in New York. This project will deliver a comprehensive computational and experimental platform for decoding, modulating, and designing protein free energy landscapes—the underlying thermodynamic structures that govern how proteins function as dynamic molecular ensembles. The primary research deliverables include the development of PF-METAD, a novel enhanced sampling computational approach that integrates hydrogen-deuterium exchange mass spectrometry (HX/MS) data into molecular dynamics simulations, along with two supporting deep learning tools (PFNet and PFBoost) for accurate residue-level determination of protection factors. These integrated tools will enable reconstruction of complete protein free energy landscapes to provide fundamental insights into protein mechanisms and support rational protein engineering for therapeutic and synthetic biology applications. The research leverages the principal investigator's established expertise in computational biophysics and HX/MS analysis to advance methods for studying dynamic protein conformational ensembles.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 5/13/26 |