Project Grant K99ES036599
- This federal Project Grant award, valued at $365,625.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the mechanisms by which TET family enzymes act on 5-methylcytosine in genomic DNA and to exploit these insights to devise controllable epigenome editors. The research, conducted by The Trustees of the University of Pennsylvania, will focus on understanding cytosine...
- The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health Federal Grant Program (CFDA 93.113), awarded a $113,168 project grant to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate how the protein XRCC1 facilitates the enzyme DNA polymerase beta (Pol β) in repairing oxidative DNA damage within chromatin. The goal is to establish the structural and mechanistic details of how XRCC1 aids Pol β in searching for,...
- This Project Grant award of $147,486 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research by Thomas Jefferson University (doing business as Sidney Kimmel Medical College) to investigate the impact of oxidative stress on centromere integrity. The key objectives are to: 1) Investigate the DNA damage response at the centromere and the contribution of DNA repair factors in maintaining centromere...
- The National Institute of Environmental Health Sciences (NIEHS) awarded a $616,715 Project Grant to the University of Southern California (USC) under the Environmental Health federal grant program (CFDA 93.113). The purpose of this 5-year grant, with a period of performance from August 1, 2025 to May 31, 2030, is to conduct research on the mechanisms by which nuclear actin filaments and phase separation promote faithful homologous recombination repair of double-strand breaks in heterochromatic...
- This Project Grant award of $950,000.00 from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research to investigate how the enzyme thymine DNA glycosylase (TDG) is regulated and targeted throughout the genome to maintain proper DNA methylation patterns. The research aims to improve understanding of how DNA methylation landscapes are established and maintained under both normal and disease conditions, which could lead to future clinical applications. The...
- The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health Federal Grant Program (CFDA 93.113), awarded a $2,518,755 Project Grant to New York University School of Medicine. The grant funding supports research to investigate the mechanisms by which the carcinogenic compound chromium(VI) induces malignant cell transformation, with a focus on the role of the protein NEDD9 and its impact on autophagy, p62 upregulation, and subsequent activation of NF-κB and Nrf2...
- This Project Grant award, valued at $646,476.00, was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113). The overarching goal of the research is to understand how environmental chemicals, such as inorganic arsenic, trigger deregulation of the epigenome that can resist epigenetic reprogramming in germ cells and become heritable. The award supports a study leveraging a model of germ cell reprogramming based...
- This Project Grant award of $451,259.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to illuminate the role of chromatin composition and regulation in the repair of double-strand breaks in heterochromatin. The research, conducted by the University of Southern California, aims to: 1) establish the function of "silent" chromatin marks in promoting early heterochromatin repair;...
- This $122,850 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health program (CFDA 93.113), supports research at Vanderbilt University to investigate the role of error-prone DNA polymerases in promoting mutagenesis and the evolution of antibiotic resistance in bacteria. The key objectives are to: 1) characterize the molecular mechanisms by which these polymerases drive transcription-associated mutagenesis, and 2) determine the...
- This Project Grant award, valued at $1,843,775.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to identify and characterize DNA-protein cross-links (DPCs) and their associated repair pathways. The principal investigator at the University of Kansas Center for Research Inc. will use advanced mass spectrometry techniques to profile the molecular signatures of DPCs across...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), provides $127,384 to the University of Pittsburgh to research the dynamics of oxidative DNA demethylation and the impact of chromatin on this process. The key objectives of the research are to: 1) determine the dynamics of the enzyme thymine DNA glycosylase (TDG) as it diffuses and binds to chromatin in living cells, and its binding to oxidized 5-methylcytosine on DNA; and 2) use cryo-electron microscopy to determine the structure of TDG when bound to nucleosomes. This work aims to elucidate how the presence of chromatin affects the efficiency of active DNA demethylation, which is an important regulatory process in gene expression. The award period runs from Sep 11, 2025 to Aug 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $127.4k | 9/9/25 |