Project Grant K99DE033483
Award Date
9/1/24
Completion Date
8/31/26
Dollars Obligated
$119K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Tucson, AZ 85721, USA
Similar Awards
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $515,812 to The Johns Hopkins University to study the progression of HPV-related oropharynx cancer (HPV-OPC) and how it differs between individuals with and without HIV. The study aims to: 1) characterize the impact of HIV on oral HPV16 persistence, 2) evaluate the performance of oral and blood biomarkers for...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $451,000.00 to the University of Chicago to conduct research aimed at deciphering the mechanisms behind patient responses to a novel immunotherapy targeting human papillomavirus (HPV) associated head and neck cancer. The key objectives of this 2-year research project are to leverage patient tumor biopsies, plasma samples,...
This federal Project Grant award of $2,740,126, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms by which HIV infection contributes to the development of oropharyngeal cancer (OPC) in people living with HIV (PWH). The key objectives are to: 1) Determine the HPV types present in OPC from PWH and how T cell-mediated anti-tumor immunity is impaired;...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $642,488 to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The funding will support a 5-year research project focused on understanding the mechanisms by which human papillomavirus (HPV) promotes immune evasion in head and neck squamous cell carcinomas (HNSCC)....
This Project Grant award of $155,500 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a comprehensive examination of the oral virome and its interactions with the oral microbiome. The research aims to shed light on the role of viruses in maintaining oral health and contributing to disease, with the goal of illuminating a neglected aspect of the oral microenvironment and potentially...
This $329,737 Project Grant awarded on September 12, 2023 by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is supporting the development of a rapid, easy-to-use diagnostic platform for the point-of-care detection of high-risk HPV in saliva. The grantee, Innotech Precision Medicine, Inc., is working to create an innovative electrochemical biosensor that combines CRISPR-Cas12 technology with their...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $808,264 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Medical University of South Carolina. The grant aims to elucidate the mechanisms underlying filopodia-mediated intracellular uptake of a cell-penetrating peptide (RD3AD) complex carrying small interfering RNAs (siRNAs), and to determine its ability to target and deliver siRNAs to migrating/invading oral...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $252,915 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Rutgers, The State University of New Jersey. The project aims to apply data science and machine learning techniques to classify aggressive tissue phenotypes and predict disease-free survival in HPV-negative head and neck squamous cell carcinoma (HNSCC). Specifically, the research will delineate molecular variations within...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to investigate the role of antiretroviral therapy (ART) on susceptibility to oral human papillomavirus (HPV) infection. The $1,913,543 award to Louisiana State University Health Sciences Center New Orleans will support three specific aims: 1) comparing the prevalence and incidence of oral HPV infection...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $315,000 to The Ohio State University to develop novel antibody therapeutics targeting the human papillomavirus (HPV) oncoproteins E6 and E7. The goal is to leverage the university's unique platform of HPV-specific human monoclonal antibodies to generate dimeric IgA molecules that can efficiently inhibit the growth of...