This $110,266 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will support research to better understand how low-risk human papillomavirus (HPV) can establish chronic infections in the vocal folds, leading to the development of recurrent respiratory papillomatosis (RRP). The project aims to define the role of vocal fold injury in facilitating HPV entry, disrupting epithelial homeostasis, and enhancing HPV gene expression, ultimately overwhelming the immune system's ability to control the infection. The research will utilize in vivo and in vitro models to investigate these mechanisms. Completion of the project is expected to have a significant and sustained impact on laryngology and papillomavirus biology, providing insights that could lead to improved prevention and management of RRP, a highly morbid laryngeal disease. The award will fund this research over a 2-year period from June 1, 2025 to May 31, 2027 at the University of Wisconsin-Madison.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $110.3k | 5/20/25 |