Project Grant K99CA312863
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $169,291 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) effective May 1, 2026, through April 30, 2028. The award funds research to characterize the cooperative role of E2F1 and interacting proteins in driving advanced prostate cancer, with particular focus on understanding neuroendocrine prostate cancer (NEPC) progression....
- Federal Project Grant Award Summary The National Cancer Institute awarded Weill Medical College of Cornell University a Project Grant totaling $1,312,608 under the Cancer Biology Research program (CFDA 93.396), effective July 10, 2025, with completion targeted for April 30, 2030. This award supports fundamental research into signal transduction to p70 S6 kinase 1 (S6K1) and mechanistic target of rapamycin complex 1 (mTORC1) signaling pathways in cancer cells. The primary research objective is to...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of Columbia University in the City of New York a Project Grant of $531,825 under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025, with completion targeted for July 31, 2030. This research initiative focuses on understanding the molecular mechanisms of castration sensitivity in prostate epithelium, with the ultimate goal of improving therapeutic responses to androgen-deprivation therapy...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $100,228.00 project grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2026, with completion anticipated by April 5, 2029. This award supports research investigating spatial and clonal dynamics in glioblastoma (GBM), an aggressive and incurable brain tumor characterized by high invasiveness, therapy resistance, and universal recurrence....
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $401,829 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective September 1, 2025, through August 31, 2028. The award funds the development of innovative single-cell molecular footprinting methodologies to map chromatin-associated protein activity in cancer cells. Specifically, the research introduces Docking & Deamination Plus...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $204,027 project grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective August 1, 2025 through July 31, 2030. This award supports the development and application of advanced single-cell and spatial technologies designed to link clonal genotypes with phenotypes during cancer evolution. The project addresses a critical gap in cancer research by...
- Federal Grant Award Summary Weill Medical College of Cornell University received a $198,164 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) on September 26, 2025, with a completion date of April 6, 2027. This award funds investigator-initiated research focused on elucidating the role of the APOBEC3 (A3) family of cytosine deaminases in driving genomic instability and somatic mutagenesis in lung cancer. The project involves...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Duke University $419,036 through the Cancer Research Manpower program (CFDA 93.398) on September 10, 2025, to support biomedical research training and career development in cancer research. This project grant, which extends through March 9, 2028, funds a research initiative titled "Manipulating Sex Hormone Signaling for Therapeutic Benefit in Liver Cancer." The award supports integrated research and training...
- Federal Project Grant Award Summary The University of Pennsylvania received a $148,626 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2025, through April 30, 2028. This award supports a research project titled "Deciphering the Role of N6-Methyladenosine (M6A) on mRNA During Adaptive Stress," which investigates the molecular mechanisms underlying prostate cancer drug resistance and metastasis. The research...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $323,860 Project Grant on August 18, 2025, to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and investigator development in cancer science. The project, titled "Investigating the Role of Mutagenic DNA Repair During the Persistence of Cancer Cells," will be conducted at the Institute's New York facility through April...
The National Cancer Institute (NCI) awarded Weill Medical College of Cornell University a $151,618 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective June 15, 2026, with completion by May 31, 2028. This award supports postdoctoral research training and career development focused on advancing the principal investigator's independent research capabilities in translational prostate cancer biology. The funded research investigates the molecular mechanisms by which MBD4 (methyl-CpG binding protein 4) regulates androgen receptor (AR) signaling and luminal cell specification in prostate cancer through integrated genomic, epigenomic, and single-cell transcriptomic analyses. The project deliverables include three primary research aims: defining MBD4's role in modulating AR function using cell-based assays, organoid models, and in vivo systems; characterizing MBD4's contribution to maintaining prostate luminal specification through single-cell transcriptomics and functional studies; and determining temporal dynamics of MBD4 downregulation during cancer progression using integrated RNA-sequencing and targeted methylation profiling. These research activities are designed to identify novel therapeutic strategies for precision AR-targeted therapy and support the candidate's transition to an independent faculty position in translational prostate cancer research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $151.6k | 6/19/26 |