Project Grant K99CA312801
- Federal Grant Award Summary Duke University's Office of Research Administration received a $120,403 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective June 1, 2026 through May 31, 2027. The award supports the development and implementation of ultrasensitive maximum depth sequencing (MDS) technology to detect occult residual pancreatic cancer disease in patients eligible for curative surgical resection. The research...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $100,228 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2026, with completion targeted for April 30, 2028. The award funds the development of a verifiable and robust deformable image registration (DIR) method to advance precision tracking of diffuse glioma progression, particularly glioblastoma (GBM). The project addresses a...
- Federal Grant Award Summary Duke University, in Durham, North Carolina, received a $402,135 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) for the period of May 1, 2026 through April 30, 2029. The award supports development and optimization of SCHICAR (Single-Cell Hi-C and Chromatin Accessibility and RNA), a novel single-cell multi-omics platform that simultaneously captures three critical data modalities: three-dimensional (3D) genome...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $415,257 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on April 24, 2026, with completion targeted for March 31, 2028. This research initiative focuses on modeling minimal residual disease (MRD) in colorectal cancer patients to identify and characterize cancer cells that persist after primary tumor resection. The project employs novel...
- Federal Project Grant Award Summary Duke University's Office of Research Administration has been awarded $1.88M in federal funding by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research integrating genome-wide association study (GWAS) data with single-cell omics technologies to identify cellular effectors of glioblastoma predisposition. The project, initiated on September 23, 2025, and scheduled for completion by August 31,...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Duke University $302,524 through the Cancer Research Manpower program (CFDA 93.398) on September 10, 2025, to support a postdoctoral fellowship research project investigating SMARCAL1 depletion and its role in enhancing immunogenicity in Alternative Lengthening of Telomeres (ALT)-positive high-grade gliomas. The project, which extends through April 30, 2028, will deliver research services encompassing both in vitro...
- Federal Grant Award Summary Duke University's Office of Research Administration has been awarded $395,846 by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) for the project period April 1, 2026 through March 31, 2031. This Project Grant supports research on therapeutic targeting of SMARCAL1 (an annealing helicase protein) as a synthetic lethal vulnerability in alternative lengthening of telomeres (ALT)-positive cancers, particularly IDH-mutant...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $2.89 million Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded September 23, 2025, with completion targeted for August 31, 2029. The project delivers development and validation of a Virtual Preclinical CT (VPCT) platform designed as a digital twin for preclinical cancer modeling of head and neck squamous cell carcinoma...
- Federal Grant Award Summary Duke University received a $2.89 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion scheduled for July 31, 2029. This research project, titled "Understanding and Targeting Epigenetic Regulation of Immune Evasion in Prostate Cancer," will investigate how epigenetic mechanisms—specifically through the TNRC18 protein—regulate immune evasion in...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $607,157 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 1, 2026, through April 30, 2031. The award funds fundamental cancer biology research focused on defining the role of tyrosine threonine kinase (TTK), also known as monopolar spindle 1 (MPS1), in neuroendocrine prostate cancer (NEPC). The research addresses an urgent...
Duke University received a $109,767 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective July 1, 2026, with completion targeted for June 30, 2038. This award supports the development and application of novel artificial intelligence (AI) frameworks to advance colorectal cancer research through interpretable pathway analysis of single-cell and spatial omics data. During the mentored K99 phase, Duke will develop SPACT and SPACT-ST—AI models designed to infer context-aware pathway activity from single-cell RNA sequencing and spatial transcriptomic data while incorporating molecular interaction networks and tissue architecture. Both tools will undergo rigorous benchmarking for accuracy, interpretability, and robustness across diverse platforms and tissue types. The independent R00 phase will deliver a publicly accessible colorectal cancer pathway atlas by analyzing large-scale datasets encompassing over 3.7 million cells from more than 250 patients. Deliverables include comprehensive characterization of pathway heterogeneity across colorectal cancer subtypes, identification of spatially organized functional programs within the tumor microenvironment, development of pathway-based cancer classifications, and discovery of candidate biomarkers linked to clinical and genomic features. These open-source resources are intended to support precision oncology applications and inform therapeutic targeting strategies for colorectal cancer treatment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $109.8k | 6/30/26 |