Project Grant K99CA307632
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $415,257 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on April 24, 2026, with completion targeted for March 31, 2028. The research focuses on modeling minimal residual disease (MRD) in colorectal cancer by developing and validating novel methodologies to identify and characterize cancer cells that persist in patients' blood...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $610,459 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 1, 2026 through April 30, 2031. The award supports fundamental research investigating NEUROD1 and cell fate plasticity in olfactory neuroblastoma (ONB), a rare and life-threatening tumor with limited treatment options. The research employs newly developed...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $411,152 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded September 5, 2025, with completion targeted for August 31, 2027. This research initiative focuses on identifying and validating noncovalent protein interactions of mutant KRAS (MKRAS) inhibitors, addressing a critical gap in understanding off-target effects of recently FDA-approved...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $402,135 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, with completion targeted for April 30, 2029. The award funds development and optimization of SCHICAR (Single-Cell High-resolution Integrated Chromatin And aRchitecture), an innovative tri-modal single-cell platform that simultaneously captures...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $123,823 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to the University of Maryland, Baltimore, effective June 1, 2026, through May 31, 2028. This grant supports research focused on characterizing transcriptomic, genomic, and microenvironmental heterogeneity in pancreatic precancerous lesions, specifically intraductal papillary mucinous neoplasms (IPMNs) and pancreatic intraepithelial...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $395,846 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to conduct research on therapeutic targeting of SMARCAL1 in therapy-resistant gliomas. The award, dated April 1, 2026, with completion scheduled for March 31, 2031, supports fundamental laboratory research aimed at identifying and validating novel therapeutic vulnerabilities in Alternative...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $1.88 million Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on September 23, 2025. The award supports a four-year research initiative (through August 31, 2029) focused on integrating genome-wide association study (GWAS) data with single-cell omics technologies to identify and characterize the cellular effectors responsible for...
- Federal Grant Award Summary Duke University received a $2.89 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion scheduled for July 31, 2029. This research project, titled "Understanding and Targeting Epigenetic Regulation of Immune Evasion in Prostate Cancer," will investigate how epigenetic mechanisms—specifically through the TNRC18 protein—regulate immune evasion in...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Virginia $161,500 under the Cancer Biology Research program (CFDA 93.396) to develop innovative methodologies for classifying circulating tumor cells (CTCs) with hybrid epithelial and mesenchymal phenotypes in pancreatic ductal adenocarcinoma (PDAC). The project, active from June 1, 2026, through May 31, 2028, delivers a perfusable co-culture system and microfluidic analytical platform designed to...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $2.89 million Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded September 23, 2025, with completion targeted for August 31, 2029. The project delivers development and validation of a Virtual Preclinical CT (VPCT) platform designed as a digital twin for preclinical cancer modeling of head and neck squamous cell carcinoma...
Duke University received a $120,403 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) for the period June 1, 2026 through May 31, 2027. The grant supports research aimed at developing ultrasensitive sequencing methodologies to detect occult residual pancreatic ductal adenocarcinoma (PDAC) tumor burden in resectable cancer patients. The project leverages maximum depth sequencing (MDS) technology to screen for oncogenic KRAS mutations in surgical resection margins and circulating tumor DNA (ctDNA) in patient blood samples, with the goal of identifying biomarkers that predict post-surgical recurrence risk and improve patient selection for curative resection procedures. The research initiative addresses a critical clinical need in pancreatic cancer management, where current imaging and CA19-9 blood test protocols prove insufficient for identifying patients at highest recurrence risk following surgery. By establishing ultrasensitive detection methods for residual disease at surgical margins and in circulation, this project aims to provide clinicians with more precise prognostic tools to stratify patients and optimize treatment decisions, ultimately improving outcomes for the majority of resectable PDAC patients who currently experience disease recurrence within five years of curative surgery.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.4k | 6/3/26 |