This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) provides $117,018 to the University of North Carolina at Chapel Hill to investigate photodynamic alterations of cell membrane lipids to enhance the efficacy of chemotherapy for metastatic ovarian cancer. The key objectives are to: 1) co-deliver polyunsaturated fatty acids and photosensitizers to initiate lipid peroxidation and "prime" cancer cells for subsequent chemotherapy, and 2) develop a nanoparticle platform to harness natural lipid trafficking mechanisms for co-delivery. This 2-year award, effective August 1, 2025, will support preclinical research to address chemoresistance in peritoneal metastases of high-grade serous ovarian carcinoma, a significant unmet clinical need.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $117.0k | 6/30/25 |