The National Cancer Institute awarded a $165,883 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, for a 2-year research project titled "Inflammation and Hepatocellular Carcinoma: A Multiomics Approach to Improve Early Detection, Causal Inference, and Lifestyle Based Prevention." The project aims to leverage genomics and proteomics data from population-based cohorts to develop improved methods for early detection of hepatocellular carcinoma, a highly lethal form of liver cancer, and investigate the role of chronic inflammation in cancer risk. Key activities include using machine learning to analyze pre-diagnostic plasma proteomics, conducting Mendelian randomization analyses to establish causal relationships, and developing an anti-inflammatory lifestyle score. This research is expected to advance the understanding of hepatocellular carcinoma biology and support the development of novel prevention and early detection strategies.
Generated 3/4/25, 8:08 AM