Project Grant K99AR084551
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Massachusetts Institute of Technology a $465,291 Project Grant effective August 1, 2025, through May 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project aims to define the determinants of colonization for commensal skin bacteria and establish foundational principles for microbiome-based therapeutic...
- Federal Grant Award Summary New York University School of Medicine received a $1.92 million Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 1, 2025, through August 31, 2028. This research project investigates the plasticity of melanocyte stem cells (MCSCs) and mature melanocytes (MCs) within adult hair follicles, specifically examining...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $249,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective July 1, 2025, through June 30, 2028. The award funds the development of a programmable small interfering RNA (siRNA)-based therapeutic platform for gene silencing in skin diseases. The research...
- Federal Project Grant Award Summary Icahn School of Medicine at Mount Sinai received a $250,396 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 5, 2025, with completion anticipated by August 31, 2027. This R21 grant supports research to unravel epigenetic and transcription control mechanisms in skin types from diverse ancestral...
- Federal Grant Award Summary Brigham & Women's Hospital received a $746,572 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded September 5, 2025, with completion targeted for August 31, 2030. The grant supports discovery and characterization of germline mechanisms underlying cutaneous immune-related adverse events (CIRAEs)—morbid and potentially...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $175,948 Project Grant to Massachusetts General Hospital (MGH) for the period of June 1, 2025 through May 31, 2030 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This career development research project investigates the molecular mechanisms through which mechanical loading and parathyroid hormone (PTH) signaling work...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded President and Fellows of Harvard College a $676,841 project grant effective August 1, 2025, through July 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project, "Leveraging Human Musculoskeletal Development to Identify Causal Disease Variants," will deliver comprehensive transcriptomic and epigenomic mapping of human...
- Federal Project Grant Award Summary Northwestern University received a Project Grant award of $134,261 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 1, 2025, through March 31, 2028. The award supports genetic and genomic analysis of Electron Transport Chain (ETC) Complex II functions in mammalian skin development, conducted at the university's...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded $224,100 in project grant funding to the Regents of the University of California at Riverside on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This three-year project, concluding August 31, 2028, will deliver research investigating epigenetic factors that control epidermal stem cell longevity in adult skin....
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Children's Hospital Corporation (Boston Children's Hospital) a Project Grant of $177,000 on August 20, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports research to identify novel modulators of limb development and chondrocyte maturation through genome-wide functional screening. The project leverages an in...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $107,784 to Massachusetts General Hospital for research on non-canonical transcriptional activation of MITF (Microphthalmia-associated transcription factor) in pigment cells, with performance occurring from May 1, 2026 through April 30, 2028. Under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), this project will deliver research services focused on elucidating a novel PKA (protein kinase A) signaling mechanism that activates M-MITF independent of the previously understood CREB1 pathway in melanocytes. The project will produce three primary research deliverables: (1) a toolkit of mutant cell lines designed to dissect canonical versus non-canonical PKA signaling events; (2) results from functional genomic screens to identify novel regulators of M-MITF using cellular proliferation and transcriptional reporter assays; and (3) molecular characterization of physical interactions between identified regulators and the M-MITF promoter. Research findings will be validated using genetically modified, induced pluripotent stem cell (iPSC)-derived primary melanocytes and organotypic skin reconstitutions to establish the physiological relevance of the mechanism. This fundamental research will advance understanding of pigmentation biology and provide the scientific foundation for developing melanocyte-specific therapeutic approaches for sun and pigmentation-related conditions, including skin cancer prevention and treatment.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $107.8k | 4/8/26 |