Project Grant K99AI201746
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $783,811 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to optimize pyrroloiminoquinone alkaloid scaffolds as antimalarial and antibabesial clinical candidates. The research program aims to develop novel chemical classes for treating malaria caused by Plasmodium falciparum and babesiosis caused by Babesia species, addressing drug resistance in...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, San Diego $240,000 on July 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Assistance Listing Project Grant R21AI202438). The research targets cryptosporidiosis, a severe diarrheal disease caused by the parasite Cryptosporidium parvum, by developing novel therapeutics that exploit the parasite's proteasome as a druggable target. The first project aim produces and...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, San Diego $240,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop new drug leads targeting F1F0 ATP synthase inhibitors for treatment of primary amoebic meningoencephalitis caused by Naegleria fowleri. The research identified two pure compounds derived from marine microbial metabolites that exhibit nanomolar potency against multiple N. fowleri...
- The National Institute of Allergy and Infectious Diseases awarded the American Foundation For Biological Research, doing business as the Biomedical Research Institute, $1.8 million on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to operate the Schistosomiasis Resource Center. The Resource Center propagates three medically important Schistosoma species—S. haematobium, S. japonicum, and S. mansoni—and distributes infected hosts (rodents and snails) and...
- Federal Grant Award Summary The University of California, San Diego received a $438,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 21, 2025, with a completion date of June 30, 2027. This award supports the development of new tools to facilitate drug discovery targeting pathogen proteasomes, which represent an emerging therapeutic target for treating parasitic...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $865,432 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to dissect the mechanisms of action of saponin combination adjuvants for vaccine development. The award funds research into saponin/monophosphoryl lipid A nanoparticles (SMNP), cage-like nanostructures that combine saponins derived from the Chilean soapbark tree with a Toll-like receptor-4 agonist. The...
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $823,548 on May 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antimalarial and antibabesial clinical candidates based on leelamine isonitrile (GB-79). The research program will evaluate the biological activity, pharmacological properties, and mechanism of action of GB-79 and its analogues against Plasmodium falciparum and Babesia species, the...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $152,600 on October 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to elucidate the molecular and cellular mechanisms by which B-alanyl tryptamine (BATT), a recently discovered schistosome pheromone, triggers female sexual maturation in schistosomes. The recipient will conduct research using transcriptomics, proteomics, and functional assays...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $125,000 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify resistance mechanisms in parasitic nematodes to anthelmintic drugs levamisole and pyrantel. The research investigates how nicotinic acetylcholine receptor (nAChR) agonists lose effectiveness against parasitic nematode infections in humans, livestock, and animals worldwide. The award funds...
- The National Institute of Allergy and Infectious Diseases awarded $157,500 to the University of California, Los Angeles on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support basic research on the structure and ligand binding of receptor adenylate cyclase from Trypanosoma brucei, a flagellated eukaryotic parasite responsible for African trypanosomiasis. The research examines cAMP signaling pathways in T. brucei, focusing on receptor-type adenylate...
The National Institute of Allergy and Infectious Diseases awarded the University of California, San Diego $184,693 on August 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to advance molecular target identification and optimization of novel small-molecule therapeutics for schistosomiasis. The award funds research to define the mechanism of action and optimize thiophenyl pyrimidine (TPP) analogs as potential alternatives to praziquantel, the single existing treatment for schistosomiasis. Work includes in vitro activity evaluation of TPP compounds across all three medically important Schistosoma species, characterization of metabolic profiles and cellular localization of TPP analogs using fluorescent probes, and identification of TPP-binding proteins to clarify how these compounds induce rapid and permanent paralysis in both adult and juvenile worms. The research aims to advance a lead candidate with oral bioavailability and physicochemical properties suitable for preclinical development. Performance occurs in La Jolla, California through July 31, 2028. This is a mentored K99 phase research career development award under which the principal investigator will conduct the work with intention to transition to an independent R00 phase.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $184.7k | 8/21/26 |