Project Grant K99AI190134
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $648,924 Project Grant to Iowa State University of Science and Technology under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The project, titled "Mosquito Extracellular Vesicles in Malaria Parasite Killing and Immune Priming," aims to obtain a mechanistic understanding of the role of mosquito extracellular vesicles in the mosquito immune system's recognition and killing of...
- This federal Project Grant award of $429,000.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The objective of this 2-year project is to: 1) Map chromatin architecture during immune activation in mosquito hemocytes, and 2) Identify gene regulatory networks for the immune deficiency (IMD) pathway genes by modulating enhancer RNA (eRNA) function. The project aims to enhance the...
- The University of Washington received a $458,849 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research aimed at uncovering the sensory mechanisms mosquitoes use to detect blood. The project seeks to leverage emerging single-cell RNA sequencing and high-throughput genetic analysis approaches to deeply characterize the diversity of sensory neurons in the mosquito labrum (feeding structure) and...
- This $401,185 Project Grant was awarded on July 18, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The funding will support research at the University of Nevada, Reno to study the mechanism of action of the broadly-active antiviral mosquito protein ABRAVO. The project aims to generate new tools, determine key protein residues, and analyze RNA and protein interactions to better...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $135,107 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Florida on June 20, 2025. The grant supports the development of a novel methodology using X-ray micro-computed tomography (micro-CT) imaging to quantify mosquito blood-feeding rates, a key determinant of pathogen transmission for mosquito-borne diseases. The project aims to optimize protocols for sample...
- The federal Project Grant award of $512,581.00 was made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research at Iowa State University of Science and Technology to investigate the influence of prostaglandin E2 on cellular and humoral immunity in the mosquito Anopheles gambiae. The research aims to examine the mechanisms of prostaglandin E2-mediated immune function, immune priming,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $423,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M University System Health Science Center. The grant, awarded on July 17, 2025, aims to develop an intein-based QF2 system for controllable protein expression in the nervous system of the Aedes aegypti mosquito. This research seeks to leverage genetic and synthetic biology tools to disrupt the propagation of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $808,919 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Boston University. The 5-year grant, which began on September 18, 2025, aims to develop novel aglain derivatives as host-targeted antivirals against dengue virus (DENV) and other mosquito-borne arboviruses. The research program seeks to optimize the aglain chemical series and study their modulation of the host...
- This $157,884 Project Grant, awarded on December 26, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the effects of a chromosomal inversion in the Anopheles coluzzii mosquito on gene regulation and its relationship to malaria resistance. The central hypothesis is that genetic variation between the inversion forms leads to differential enhancer activity and gene...
- This Project Grant award of $2,536,503 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the ability of Aedes aegypti mosquitoes to tolerate desiccation affects their potential as disease vectors. The research aims to identify genetic mechanisms linking desiccation tolerance to susceptibility to Zika, Chikungunya, and Dengue viruses in the mosquito midgut. Key...
This federal Project Grant award of $152,527 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the processes mediating mosquito basement membrane repair and the implications on within-mosquito virus dynamics. The research aims to investigate the spatiotemporal expression of basement membrane genes and proteins following mosquito blood feeding, as well as create transgenic mosquito lines to identify the tissue of origin for proteins incorporated into the repairing basement membrane. This will help determine the relative importance of different tissues involved in the basement membrane repair process and its impact on virus dissemination within the mosquito. The project will be conducted by the Connecticut Agricultural Experimental Station, a state government research entity, over a period from August 2025 to July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $152.5k | 8/4/25 |