Project Grant K99AI187628
- This $195,640 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year research program at Johns Hopkins University to study the vaginal microbiome and its contributions to bacterial vaginosis (BV). The research aims to evaluate mechanisms for treatment failure and identify subpopulations that may respond better to the antibiotic clindamycin versus the more commonly prescribed metronidazole....
- The federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will provide $511,763 to Seattle University to conduct activity-based protein profiling of the vaginal microbiome. The goal is to understand how enzymes related to glycogen degradation and microbial proteases are associated with vaginal community composition and bacterial vaginosis. The 3-year project,...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
- This federal Project Grant award of $243,750 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate how the bacterium Gardnerella promotes the pathogenesis of Neisseria gonorrhoeae, the causative agent of the sexually-transmitted infection gonorrhea. The key objectives are to determine the mechanisms by which Gardnerella virulence factors, including the cytolytic toxin...
- This $402,731 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), authorized under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund a program to increase the number of next-generation physician-scientists who can apply knowledge of microbiology, immunology, and research techniques to improve reproductive, maternal, and child health. The award will support 4 physician-scientists in pediatrics or obstetrics/gynecology residency...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute in La Jolla, CA to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The researchers will employ chemical biology and proteomics methods to identify specific microbiota-associated bile acid protein targets in mammalian cells...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $300,000 in funding to Topaz Biosciences, Inc. to discover and optimize novel endolysins that can selectively target Gardnerella vaginalis, the primary bacterial species associated with bacterial vaginosis (BV). The goal is to develop improved endolysins that are more active, thermostable, and pH tolerant than...
- This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the menstrual cycle and associated immune changes impact the development of chlamydia and gonorrhea infections in women and adolescent girls. The $2,112,000 grant was awarded to Emory University on September 22, 2025, with a final completion date of August 31, 2029. The...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $216,264 to the University of Colorado-Denver to characterize the interactions between Group B Streptococcus (GBS) and Candida albicans (CA) within the gastrointestinal and female reproductive tract. The research aims to determine how CA's transcriptional reprogramming of GBS impacts vaginal colonization and disease,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $112,956 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M University System Health Science Center (TAMU HSC) on December 26, 2024. The overall goal of this research project is to define the role of sex-specific traits in influencing energetic trade-offs that underlie innate immune responses and dictate infection susceptibility using the Drosophila melanogaster...
This Project Grant award, valued at $126,460 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify ecological drivers of dysbiosis in the female reproductive tract. The research will use genetically tractable uropathogenic E. coli and specialized animal and tissue culture models to determine how host cell metabolism controls vaginal community composition and perpetuates chronic aerobic vaginitis. The key focus is on understanding how hormone-induced metabolic reprogramming of the host epithelium towards aerobic glycolysis increases luminal oxygenation, allowing E. coli to outcompete anaerobes and trigger an inflammatory response. The award period runs from August 21, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $126.5k | 8/21/25 |