This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $152,324 to The Leland Stanford Junior University to study the role of CXCL13 in age-related defects in memory T cell homeostasis. The research aims to reveal the cellular and molecular mechanisms by which CXCL13 maintains memory T cells, and to define the specific T cell populations impacted by CXCL13...
The federal Project Grant award R01AI186945 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for $625,348 with a period of performance from Jul 3, 2025 to Jun 30, 2030. The grant supports research at the University of Utah to define the role of the NF-kB signaling network in regulating affinity maturation and the generation of plasma cells and memory B cells. The goal is to improve...
The federal Project Grant award R21AI185033 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of the APOBEC3B enzyme in the innate immune response against RNA viruses such as SARS-CoV-2, HIV-1, and Hepatitis B. The $228,435 award, effective January 2, 2025 through December 31, 2026, will fund research at the University of California, Irvine to identify novel...
This Project Grant award, valued at $735,078, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports a 5-year research project to investigate the molecular mechanisms of innate immune memory in humans, with a focus on understanding the epigenetic determinants that enable long-lasting "trained immunity" in myeloid and lymphoid progenitor cells. The...
The federal Project Grant award R01AI192874 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $649,530 award supports research to understand how B cells and their antibody receptors can contribute to protection from or susceptibility to dengue virus infection and disease progression. The project aims to define the mechanistic requirements underpinning B cell receptor-dependent...
This $435,875 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of California, Merced to interrogate the role of the transcriptional regulator NFKBID in humoral immunity against the parasite Toxoplasma gondii. The research aims to define how NFKBID-deficient T follicular helper cells impact B cell antibody responses, and examine the contribution of NFKBID-dependent...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $247,750 to support structural investigations of the SARS-CoV-2 spike protein. The research aims to characterize how glycosylation (the addition of sugar molecules) of the spike protein affects its structure and function, which is critical for virus entry and immune system interactions. This research will...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $242,310 to Emory University to study how genetic diversity in the immunoglobulin heavy chain locus impacts the development of neutralizing antibodies against the HIV envelope protein. The project aims to: 1) Identify polymorphisms in rhesus macaques vaccinated with the BG505 SOSIP.664 HIV immunogen that are associated with differential...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $130,368 to President and Fellows of Harvard College, doing business as Harvard Medical School, to define how B cell receptor binding site copy number is developmentally regulated to optimize antigen recognition and support affinity-driven antibody selection within B cell germinal centers. The research aims to...