Project Grant K99AI185160
- The University of Massachusetts Medical School (UMMS) was awarded a $840,687 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the grant is to conduct research to "Decipher the Role of Bruton's Tyrosine Kinase in the Host Defense Against Aspergillus Fumigatus". The key objectives are to investigate how inhibition of the Bruton's Tyrosine Kinase (BTK) enzyme...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $807,799 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the University of Chicago. The grant, which runs from Jul 15, 2025 to Jun 30, 2030, supports research to investigate the role of a specialized subset of regulatory T cells in controlling self-reactive B cells and the production of autoantibodies. The research aims to identify these B cell-dependent...
- This $441,202 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is funding research to study the role of effector regulatory T cells (ExTregs) in autoimmunity and cancer immunity. The project aims to utilize genetic tracing models to monitor ExTregs and assess their contribution to immune responses when regulatory T cells (Tregs) are depleted. The research seeks to provide...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $435,875 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Merced. The grant, titled "Interrogating NFKBID Dependent Humoral Immunity to Toxoplasma gondii", seeks to understand the mechanisms by which the transcriptional regulator IKBNS (encoded by NFKBID) mediates protective immunity against the parasitic infection Toxoplasma gondii. The...
- This $838,320 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant will fund research to investigate fungal pathogenicity determinants and their relationship to emerging cancer therapies that can lead to increased risk of invasive fungal infections. Specifically, the research aims to understand the mechanism by which inhibition of the Bruton's...
- This $3,288,215 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The University of Texas MD Anderson Cancer Center. The project, titled "Role of GRAIL in B Cell Tolerance and B-Cell Mediated Inflammation," aims to investigate the role of the E3 ubiquitin ligase gene GRAIL in B cell tolerance and its potential as a marker for the onset of B...
- This $550,375 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant will fund research to comprehensively understand the mechanisms by which the transcription factor BATF regulates natural killer (NK) cell survival, proliferation, and effector function in the context of viral infections and anti-tumor immunity. Key objectives include: 1) Assessing the...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $3,018,216 to the University of Chicago to conduct research on the role of the BRWD1 protein in regulating chromatin topology and gene expression in developing B cells and germinal center B cells. The research aims to define how BRWD1-mediated cohesin dynamics contribute to essential B cell functions, such as...
- The University of Pittsburgh was awarded a $379,609 Project Grant by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to investigate how the immune system establishes homeostasis with commensal microbes. The research aims to understand the mechanisms through which B cells balance the need for a diverse repertoire with maintaining self-tolerance, including the potential role of anergized B cells in this process. The award period is...
- This $489,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research grant program (CFDA 93.855), supports research to overcome technical obstacles in understanding the assembly and regulation of B cell antigen receptors (BCRs). The award aims to develop effective adaptive immunity following infection and vaccination by engineering appropriate cell lines and utilizing native membrane environments to study BCR...
This $117,883 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) on September 1, 2025. The grant will support research at the University of California, Berkeley to investigate the role of Bruton's tyrosine kinase (BTK) in maintaining B-cell anergy, which is critical for preventing autoimmunity. The research aims to elucidate how BTK's unique ability to dimerize on the plasma membrane helps control the balance between B-cell anergy and responsiveness. Specifically, the grant will fund efforts to: 1) determine how BTK dimerization facilitates membrane adsorption, 2) develop microscopy approaches to examine how dimerization underlies B-cell signaling, and 3) assess how modulating BTK dimerization alters the fraction and signaling of anergic B cells. This work has potential implications for developing BTK-targeted therapies for autoimmune disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $117.9k | 9/2/25 |