The diabetic wound environment shapes group b streptococcal pathogenesis
Ended Project Grant Awarded Last action
- Award ID
- K99AI180373
- Recipient
-
The Regents Of The University Of Colorado UEI MW8JHK6ZYEX8 Part of The Regents Of The University Of Colorado
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $568,184
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date
- Place of performance
- Aurora, CO 80045, USA
Award details come from USAspending.gov.
Description
- Abstract
- Diabetic wound infections are a major public health burden, with approximately 25% of diabetic individuals developing a wound in their lifetime, 25% of these wounds not healing and 28% requiring surgical amputation. The diabetic wound environment is complex, with hyperglycemia driving immune dysfunction and bacterial pathogenesis leading to poor infection outcomes. One of the most frequently isolated bacterial species from diabetic wound infections is group b streptococcus (GBS). Interestingly, GBS is notoriously absent from non- diabetic wounds, suggesting that components of the diabetic environment specifically influence GBS success in this niche. Previously, i have developed two murine models of GBS diabetic wound infection and determined that GBS promotes hyper-inflammation in vivo. Dual RNA-sequencing of the murine and GBS transcriptome has identified multiple host and bacterial targets with altered transcription during diabetic infection that have informed the hypothesis herein. This proposal therefore seeks to elucidate the environmental factors that promote GBS infection of diabetic wounds. I hypothesize that multiple facets of the diabetic wound environment including neutrophil function, hyperglycemia and polymicrobial interactions contribute to GBS success. This hypothesis will be addressed via the following specific aims: aim 1: evaluate the consequences of altered neutrophil function to GBS pathogenesis during diabetic wound infection. Aim 2: determine how hyperglycemia contributes to GBS pathogenesis in the diabetic wound. Aim 3: examine the contribution of staphylococcus aureus to GBS diabetic wound persistence during polymicrobial infection. These studies will increase our understanding of how the diabetic wound differs from the non-diabetic wound environment, and the consequences of that altered environment on pathogen success.
Transactions
| Action | Obligated | Date |
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| Amendment | $0 | |
| Amendment | -$15,908 | |
| Amendment | -$15,908 | |
| Amendment | $100,000 | |
| Amendment | $100,000 | |
| Amendment | $100,000 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
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| Amendment | $100,000 | |
| Amendment | $100,000 | |
| Original award | $100,000 |
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Quick answers
Who received award K99AI180373?
K99AI180373 was awarded to The Regents Of The University Of Colorado by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on June 13, 2024.
How much is award K99AI180373 worth?
$568,184 has been obligated on K99AI180373.
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