The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $220,656 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division. The grant will fund research to investigate the effects of ethanol metabolism on the sorting of non-isgylated HIV proteins to hepatocyte-derived exosomes, and how these exosomes impact the pro-fibrotic activation of hepatic stellate...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the federal Alcohol Research Programs (CFDA 93.273), provides $698,356 to Brown University to study the relationship between alcohol-associated gut dysbiosis and cardiovascular disease (CVD) risk in people with HIV. The key objectives are to: 1) characterize alcohol-associated gut dysbiosis using whole genome sequencing of fecal samples; 2) examine how gut microbiome changes at the...
This $442,898 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to define the contributions of macrophage migration inhibitory factor (MIF) and its receptor CD74 in alcohol-associated liver disease (ALD). The research plan includes three specific aims: 1) characterizing the role of CD74 expression in hepatocytes and myeloid cells during and after ethanol feeding in mice, 2) resolving the...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,547,718 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from September 1, 2024 to May 31, 2029. The project will investigate the role of KDM5 demethylases in regulating cell-cell communication in the development and resolution of alcohol-associated liver disease. Specifically, the research aims to determine how KDM5B and KDM5C...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to examine the role of non-parenchymal cells (NPCs) in driving the key features of Alcohol Associated Hepatitis (AAH) in a fully humanized mouse liver model. The $688,199 award to Yale University will fund research over a 5-year period from June 1, 2025 to February 28, 2030. The research aims to elucidate the NPC-derived...
This Project Grant award of $1,158,934.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), will fund research to understand the mechanisms of mitochondrial dynamics, quality control, and mitochondrial DNA-mediated inflammation in alcohol-associated liver disease (ALD). The key objectives are to investigate how chronically accumulated megamitochondria in the liver promote the release of mitochondrial DNA and activation of...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will provide $119,600 over a 3-year period from July 2024 to July 2027 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to conduct research on the mechanisms by which aging and alcohol consumption cooperatively contribute to the development of alcohol-associated liver disease (ALD). The project aims to identify how...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and testing of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific characterization of the human microglial response to alcohol exposure. The $214,385 award, with a period of performance from August 2024 to July 2026, will fund research...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $123,045 to Louisiana State University Health Sciences Center New Orleans to investigate the role of the TRAF3IP2 protein in the pathogenesis of alcohol-related cardiomyopathy. The research aims to determine whether alcohol-induced cardiac fibroblast activation and inflammatory/fibrotic responses are dependent on TRAF3IP2, and whether global...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...