Project Grant K23MH144291
- The National Institute of Mental Health awarded Northwestern University $400,000 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate seizure networks in electroconvulsive therapy outcomes. The research will characterize how seizure activity progresses through brain regions and networks during ECT in treatment-refractory depression, with focus on understudied seizure-network nodes including piriform cortex, substantia nigra, and cerebellar nuclei that...
- The National Institute of Mental Health awarded the University of California, Los Angeles $433,125 under the Mental Health Research Grants program (CFDA 93.242) on June 15, 2026, to examine cell-free DNA as a biomarker of electroconvulsive therapy in treatment-resistant depression. The research investigates the dynamics of circulating cell-free DNA in patients with treatment-resistant depression undergoing FDA-approved electroconvulsive therapy, using infrastructure from an ongoing NIMH-funded...
- The National Institute of Mental Health, under the Department of Health and Human Services, awarded the University of California, San Diego $199,271 on September 1, 2026, for a randomized, double-blind, sham-controlled trial of home-based spaced transcranial direct current stimulation (tDCS) in adults with treatment-resistant depression. The award funds investigation of a novel spaced tDCS protocol—involving multiple daily sessions separated by short intervals—designed to better engage...
- The National Institute of Mental Health awarded Vanderbilt University Medical Center $186,624 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242, K23 award K23MH140069) to conduct a randomized clinical trial pilot study examining cognitive enhancement interventions for late-life depression with executive dysfunction. The study enrolls sixty non-demented older adults presenting with executive dysfunction and recurrent late-life depression in a four-week daily...
- The National Institute of Mental Health awarded The Research Foundation for The State University of New York $437,125 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a preliminary positron emission tomography study quantifying the mechanism of transcranial magnetic stimulation in depression. The recipient, operating as Stony Brook University, will investigate the relationship between repetitive transcranial magnetic stimulation (rTMS)—an FDA-approved...
- The National Institute of Mental Health awarded Brigham & Women's Hospital Inc. $863,825 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a double-blind, confirmatory efficacy trial comparing imaging-based targeting versus scalp-targeted accelerated transcranial magnetic stimulation (ATMS) for treatment-resistant major depressive disorder. The trial will enroll 120 participants to test whether imaging-targeted ATMS, using Stanford Accelerated...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $1,066,793 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026, to develop and validate a personalized repetitive transcranial magnetic stimulation (rTMS) protocol for treatment-resistant depression using electrophysiological biomarkers. The award funds an R61/R33 phased study that will use early local TMS-evoked potentials (EL-TEPs)—measurements of prefrontal excitability—to...
- The National Institute of Mental Health awarded the University of California, San Diego $1,553,622 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a confirmatory efficacy trial of gamma EEG-neurofeedback treatment targeting working memory deficits in individuals with schizophrenia. The award funds a randomized clinical trial designed to confirm efficacy of a neuromodulation intervention that uses real-time EEG neurofeedback to increase synchronous...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $197,614 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop electroencephalographic biomarkers for the diagnosis and monitoring of catatonia. The award funds a K23 mentored patient-oriented research career development grant led by Principal Investigator James Luccarelli, MD, DPhil. The research uses detailed clinical phenotyping and machine...
- The National Institute of Mental Health awarded Trustees of Dartmouth College $114,152 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research determining and enhancing the cellular selectivity of transcranial magnetic stimulation using optical physiology and computational models. The funded research directly tests predictions about how transcranial magnetic stimulation (TMS)—an FDA-approved treatment for drug-resistant depression,...
The National Institute of Mental Health awarded the University of New Mexico Health Sciences Center $194,779 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242, K23 Career Development Award K23MH144291) to investigate brain excitability, seizure expression, and cognitive outcomes in electroconvulsive therapy for late-life depression. The research, titled CEASE-LD (Characterizing Brain Excitability, Adequacy of Seizures, and Efficacy in Late-Life Depression with ECT), enrolls 50 older adults with late-life depression undergoing clinically indicated ECT. Each participant undergoes amplitude-based seizure titration to measure baseline brain excitability, followed by fixed-amplitude treatment. Structural MRI models electric field strength, and ictal EEG is recorded with a 32-lead cap. The three study aims evaluate how amplitude-based titration and electric field influence seizure characteristics; examine the relationship between seizure features and antidepressant response, including within-subject changes during dose escalation; and assess relationships between seizure expression, electric field strength, and cognitive outcomes with emphasis on verbal fluency. The work is performed in Albuquerque, New Mexico, with a period of performance through August 31, 2031. The training plan includes mentorship from Dr. Christopher Abbott (University of New Mexico) on ECT dosing and Dr. Shawn McClintock (University of Texas Southwestern) on cognitive outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.8k | 8/21/26 |