Project Grant K23MH143065
- The National Institute of Mental Health awarded New York University School of Medicine $100,228 on November 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project examining cerebellar contributions to schizophrenia spectrum disorders. The research uses multimodal neuroimaging techniques—resting-state functional MRI, diffusion MRI, and multi-echo gradient imaging—to investigate how cerebellar abnormalities contribute to cognitive deficits in young adults...
- The National Institute of Mental Health awarded The Washington University $197,600 on September 28, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the cognitive and neurobiological underpinnings of reduced motivation and pleasure symptoms in psychotic and mood disorders with psychosis. The project integrates ecological momentary assessment, repeatable mobile cognitive testing, naturalistic fMRI stimuli, and individual-specific functional connectivity...
- The National Institute of Mental Health awarded The Johns Hopkins University $807,893 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced magnetic resonance imaging research on neurovascular abnormalities in individuals with schizophrenia across the life span. The recipient will perform quantitative MR imaging at 7 Tesla field strength to test the hypothesis that cerebral microvasculature and cerebrospinal fluid circulation and clearance...
- The National Institute of Mental Health awarded Yale University $827,899 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to deconstruct delusion mechanisms via causal learning in individuals with schizophrenia. The research examines the roles of social and non-social prediction errors in delusions by comparing patients with schizophrenia to control participants without delusions across three specific aims. Aim 1 uses social and non-social Kamin blocking tasks...
- The National Institute of Mental Health awarded $191,910 to the University of Manitoba on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize neural abnormalities associated with aberrant predictive learning in schizophrenia and their relationships with specific illness features over time. The recipient will conduct an electroencephalography (EEG) study of auditory predictive learning using a Bayesian computational framework. The study enrolls 90 adults...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $3.084 million on June 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop decoded functional magnetic resonance imaging neurofeedback as a novel treatment for auditory verbal hallucinations in schizophrenia. The project will test decoded neurofeedback, an fMRI-based technique that enables individuals to modify brain activation patterns in real time through...
- The National Institute of Mental Health awarded The Washington University $763,894 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ZNF292 gene in cortical development and neurodevelopmental disorders. The research employs complementary experimental systems—mouse knockout models and human pluripotent stem cell-derived neurons carrying six pathogenic ZNF292 variants identified in patients with autism spectrum disorder, intellectual...
- The National Institute of Mental Health awarded The Washington University $140,109 on June 1, 2026, to develop, disseminate, and sustain cloud-based software tools for optical brain mapping under the Mental Health Research Grants program (CFDA 93.242). The award funds sustainable development, dissemination, and training for scalable software resources that standardize processing workflows in optical neuroimaging, specifically functional near infrared spectroscopy (fNIRS) and high-density diffuse...
- The National Institute of Mental Health awarded The Washington University $735,920 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms of threat learning and avoidance behaviors. The research elucidates the temporal dynamics and causal roles of neurons in the supramammillary nucleus during threat learning, avoidance, and extinction using fiber photometry, optogenetics, and behavioral assays. The project determines whether these...
- The National Institute of Mental Health awarded the University of Washington $427,625 on June 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct molecular studies of dopamine neuron subpopulations in the ventral tegmental area. The award funds research combining slice electrophysiology recordings with post-hoc single-cell sequencing analysis (patch-seq) to correlate gene expression and physiological properties across distinct dopamine neuron populations. The...
The National Institute of Mental Health awarded The Washington University $197,612 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating non-invasive cerebellar stimulation and predictive coding in schizophrenia. The project addresses neurobiological mechanisms underlying delusions in schizophrenia by testing whether cerebellar dysfunction contributes to predictive coding deficits—errors in the brain's ability to update internal models that generate predictions about the external world. The study uses transcranial direct current stimulation (TDCS) to modulate cerebellar circuitry and measure causal impacts on behavioral, computational, and neural measures of predictive coding in patients with schizophrenia (N=90). Participants will be enrolled in a three-session within-person, active-sham cross-over study design that includes baseline clinical and behavioral assessments across multiple sessions. Performance occurs at The Washington University's Office of Sponsored Research Services in University City, Missouri. The award period runs from September 1, 2026, through August 31, 2031. This is a K23 award, a career development grant made for up to five years with no renewal option under NIMH's individual mentored research career development framework.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $197.6k | 8/28/26 |