Development and pilot RCT of a "healthy welcome" intervention to increase prep uptake and adherence among migrant men in johannesburg

Active Project Grant Awarded Last action

Award ID
K23MH134771
Recipient
Awarding agency
Obligated
$398,028

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 43% complete
Originally
Place of performance
Boston, MA 02115, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Background: south africa has one of the largest rates of migration on the african continent, largely comprised of migrant men, who are at high risk of HIV acquisition. Pre-exposure prophylaxis (prep) is effective at preventing HIV. Migrant men face barriers to prep use, including lack of prep knowledge, stigma at clinics, and unfamiliarity about health services in new settings. To decrease the incidence of HIV in south africa, interventions are needed to promote prep use among migrant men in south africa. The goal of this proposal is to develop and pilot test a "healthy welcome" intervention to support migrant men in starting and adhering to prep by linking them to community pharmacies. Candidate: i am an internal medicine physician and an associate scientist at brigham and women's hospital (harvard medical school). I am applying for a five-year K23 career development award to obtain the training and research experience that will allow me to become an independent investigator at the R01 level and an expert in developing interventions to promote engagement in HIV services among migrant populations globally. Mentoring: DRS. Ingrid katz and jessica haberer will serve as my CO-primary mentors. DR. Katz brings expertise in behavioral components of intervention development and strategies to track hard-to-reach populations in south africa. DR. Haberer brings expertise in prep clinical trials, including implementation science, the concept of "prevention-effective" (p-e) adherence to prep, and mobile health strategies. CO-mentor prof. Terris-prestholt will provide mentorship on discrete choice experiment (DCE) methodology. Profs. Pascoe and setswe, south africa-based CO-mentors, will provide mentorship on local application of DCE methods and behavioral economics (be) strategies for intervention development (pascoe) and community engagement and local implementation (setswe). Profs. Miot and venter, south-africa based members of my scientific advisory board (SAB), will offer guidance on integrating my proposed study within an existing gates-funded project to offer prep through community pharmacies in south africa and on policy implications of study findings. SAB member prof. Lurie will offer guidance on engaging migrant men. SAB member prof. Thirumurthy will guide me on be theoretical frameworks. SAB member smeaton will provide statistical expertise to guide the pilot randomized controlled trial (RCT). Training: training in DCE methodology, be strategies, and pilot rcts for prep will be achieved through intensive direct mentorship and coursework. Research: the specific aims are to 1) elicit preferences for prep services among migrant men through a DCE; 2) design a "healthy welcome" intervention for migrant men to promote linkage to pharmacies for prep uptake and adherence; and 3) evaluate the feasibility, acceptability, appropriateness, and fidelity of the intervention through a pilot RCT. I will use this formative research to apply for an R01-level grant to evaluate the efficacy and effectiveness of the intervention.

Transactions

Action Obligated Date
Amendment $0
Amendment $0
Amendment $31,208
Amendment $165,814
Original award $201,006

Subawards

Subrecipient Amount Awarded
Wits Health Consortium (Pty) LTD This study proposes to test the feasibility and acceptability of a brief "Healthy Welcome" intervention developed to increase PrEP uptake and adherence among… $31,208

Quick answers

Who received award K23MH134771?

K23MH134771 was awarded to Brigham & Womens Hospital Inc. by National Institute of Mental Health (National Institutes of Health) on July 15, 2024.

How much is award K23MH134771 worth?

$398,028 has been obligated on K23MH134771.

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