Project Grant K23HL188353
- The National Heart, Lung, and Blood Institute awarded Children's Research Institute $126,518 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to build a patient-oriented research mentoring program in human neonatal and infant airway biology. The award funds mentoring and research addressing mechanisms regulating airway epithelial immune responses in early life, with particular focus on populations historically excluded from respiratory research: infants with...
- The National Heart, Lung, and Blood Institute awarded Kaiser Foundation Hospitals $780,960 on July 3, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to evaluate treatment adherence interventions for young adults with obstructive sleep apnea. The award funds a five-year randomized controlled trial testing two interventions designed to improve continuous positive airway pressure (CPAP) treatment adherence among young adults ages 18–25. The research addresses a documented...
- The National Heart, Lung, and Blood Institute awarded Brigham & Women's Hospital Inc. $492,250 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct data-driven phenotyping of obstructive sleep apnea and sex-specific cardiovascular consequences. The research integrates high-dimensional physiological and clinical data from the Mass General Brigham Health System electronic health record cohort, which includes over 144,000 patients with structured records...
- The National Heart, Lung, and Blood Institute awarded The Children's Hospital of Philadelphia $128,466 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a patient-oriented research program led by Dr. Elizabeth Foglia, an Associate Professor of Pediatrics in the Division of Neonatology, focused on improving neonatal respiratory outcomes by optimizing non-invasive ventilation and improving neonatal airway management. The award funds a K24 mentoring...
- The National Heart, Lung, and Blood Institute awarded Emma Pendleton Bradley Hospital $175,175 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and implement a digital sleep intervention for preschoolers in foster care. The award funds development, pretesting, and evaluation of Nurturing Sleep, a trauma-informed digital public-health-level sleep intervention administered to foster caregivers of children ages 36–71 months. Aim 1 involves...
- The National Heart, Lung, and Blood Institute awarded The Trustees of the University of Pennsylvania $1.542 million on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to improve understanding of sleep apnea pathogenesis using novel imaging techniques during sleep. The research combines drug-induced sleep endoscopy (DISE) with dynamic magnetic resonance imaging (MRI) to characterize upper airway anatomy and the mechanisms of airway collapse during sleep. The...
- The National Heart, Lung, and Blood Institute awarded Children's Research Institute $1,818,088 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate how postnatal hypoxemia—reduced blood oxygen levels present in cyanotic congenital heart disease—impacts cardiac maturation and surgical recovery outcomes in pediatric patients. The project will examine the interaction between hypoxemia, myocardial immaturity, and postoperative complications through...
- The National Heart, Lung, and Blood Institute awarded $316,609 to Remplenish, Inc. on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a novel myofunctional nipple device for preventing obstructive sleep apnea in infants. The recipient will design and validate a low-risk, low-burden device that delivers myofunctional therapy—oropharyngeal exercises integrated into infant bottle feeding—as a non-invasive first-line treatment and preventive measure...
- The National Heart Lung and Blood Institute awarded New York University School of Medicine $795,421 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sex-specific responses to obstructive sleep apnea therapies. The research examines how oxidative stress mediates cardiovascular harm from obstructive sleep apnea, with particular focus on sex differences in treatment response. The study tests N-acetylcysteine, an antioxidant precursor that...
- The National Heart, Lung, and Blood Institute awarded Seattle Children's Hospital $1,736,235 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sleep health and its relationship to childhood systemic lupus erythematosus (CSLE) symptoms within the sociocultural and neighborhood contexts of affected youth. The research examines associations between sleep health dimensions—including duration, efficiency, regularity, and daytime sleepiness—and CSLE...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital $171,600 on September 1, 2026, under CFDA 93.837 (Cardiovascular Diseases Research) to support career development and mentored research in pediatric obstructive sleep apnea diagnostics. The award funds the recipient investigator's training in three areas: predictive modeling and machine learning, advanced physiological signal analysis, and implementation science for translating research into clinical practice. The research project validates novel ventilatory biomarkers as diagnostic tools for pediatric OSA and tests their clinical utility against the current standard Apnea-Hypopnea Index, which correlates poorly with neurobehavioral outcomes and treatment response. The work will analyze existing data from two landmark NIH-funded randomized trials—the Childhood Adenotonsillectomy Trial (CHAT, N=453) and Pediatric Adenotonsillectomy Trial for Snoring (PATS, N=459)—and recruit 50 children for a prospective pilot study. Mentorship is provided by Drs. Susan Redline (sleep medicine and epidemiology), Ali Azarbarzin (novel OSA biomarkers), and Hudson Taylor (neuropsychological assessments). The period of performance runs from September 1, 2026, through August 31, 2031. Work is performed in Boston, Massachusetts. This is a Project Grant under the K23 (Mentored Patient-Oriented Research Career Development Award) mechanism, a training-focused award category within the broader Cardiovascular Diseases Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $171.6k | 8/28/26 |