Project Grant R01HL181640
- The National Heart, Lung, and Blood Institute awarded the University of California Irvine a project grant of $214,071 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research investigating the cardiac response to obstructive sleep apnea through an in-vitro heart-on-a-chip platform combined with intermittent hypoxia protocols. The research will develop and validate physiologically relevant intermittent hypoxia protocols using endothelial...
- The National Heart, Lung, and Blood Institute awarded The Trustees of the University of Pennsylvania $1.542 million on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to improve understanding of sleep apnea pathogenesis using novel imaging techniques during sleep. The research combines drug-induced sleep endoscopy (DISE) with dynamic magnetic resonance imaging (MRI) to characterize upper airway anatomy and the mechanisms of airway collapse during sleep. The...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $166,248 on September 26, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research triangulating causal effects of sleep, inflammation, and cardiometabolic disease. The research will identify oxylipin biomarkers associated with sleep problems—including insomnia, sleep apnea, and short sleep duration—and their relationship to cardiometabolic disease. The study...
- The National Heart, Lung, and Blood Institute awarded Brigham & Women's Hospital Inc. $492,250 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct data-driven phenotyping of obstructive sleep apnea and sex-specific cardiovascular consequences. The research integrates high-dimensional physiological and clinical data from the Mass General Brigham Health System electronic health record cohort, which includes over 144,000 patients with structured records...
- The National Heart, Lung, and Blood Institute awarded Emory University $100,228 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct longitudinal research examining associations between sleep health, protective factors against psychosocial adversity, and stress-related biomarkers including allostatic load and epigenetic age acceleration. The project analyzes multidimensional sleep health—encompassing regularity, satisfaction, alertness, timing,...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, Irvine a $1,296,660 Project Grant on September 25, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a comprehensive "Bed to Bench" evaluation of the cardiac and vascular impact of obstructive sleep apnea (OSA). The research will address critical knowledge gaps in understanding the mechanistic pathways linking OSA to...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Northern California Institute For Research And Education, Inc. (NCIRE) a $1,270,508 Project Grant effective September 20, 2025, through August 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). The project delivers three primary products and services: (1) identification of health factors associated with obstructive sleep apnea (OSA) in women through analysis of electronic health...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $450,000 in funding to Old Dominion University to investigate the relationship between disturbed sleep and the development of vulnerable atherosclerotic plaques. The primary objectives are to: 1) examine the role of NADPH-dependent oxidative stress in accelerating the formation of vulnerable atherosclerotic plaques in...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital $171,600 on September 1, 2026, under CFDA 93.837 (Cardiovascular Diseases Research) to support career development and mentored research in pediatric obstructive sleep apnea diagnostics. The award funds the recipient investigator's training in three areas: predictive modeling and machine learning, advanced physiological signal analysis, and implementation science for translating research into clinical...
- The National Heart, Lung, and Blood Institute awarded Berendo Scientific LLC $583,718 in project grant funding on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to optimize and evaluate the SLEEPFLEX head and neck exercise program for treating mild to moderate obstructive sleep apnea. The recipient will develop a non-invasive treatment delivering targeted head and neck exercises via smartphone application (iOS and Android) with instructional videos and...
The National Heart Lung and Blood Institute awarded New York University School of Medicine $795,421 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sex-specific responses to obstructive sleep apnea therapies. The research examines how oxidative stress mediates cardiovascular harm from obstructive sleep apnea, with particular focus on sex differences in treatment response. The study tests N-acetylcysteine, an antioxidant precursor that boosts glutathione pools, as a potential alternative therapy for moderate-to-severe obstructive sleep apnea in middle- and older-aged adults (ages 52–70). The project addresses the heightened cardiovascular vulnerability of postmenopausal women, whose loss of estrogen-based antioxidant defense coincides with sharply rising obstructive sleep apnea prevalence and who may respond differently than men to candidate therapies. Place of performance is New York, New York 10016. The period of performance runs from September 1, 2026, through June 30, 2031. This is a Project Grant, the standard NIH research grant mechanism for investigator-initiated hypothesis-driven projects reviewed through competitive peer evaluation by study section and advisory council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $795.4k | 8/31/26 |