Project Grant K23HL186285
- The National Heart Lung and Blood Institute awarded New York University School of Medicine $795,421 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sex-specific responses to obstructive sleep apnea therapies. The research examines how oxidative stress mediates cardiovascular harm from obstructive sleep apnea, with particular focus on sex differences in treatment response. The study tests N-acetylcysteine, an antioxidant precursor that...
- The National Heart, Lung, and Blood Institute awarded Icahn School of Medicine at Mount Sinai $839,536 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate how lifestyle factors selectively modify clonal hematopoiesis in atherosclerosis through immuno-metabolic reprogramming. The research will examine whether sleep and exercise—evolutionarily conserved behaviors that promote cardiovascular and immune health—can modify the evolution of clonal...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $816,472 (awarded August 1, 2025, with completion targeted for May 31, 2029) under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate advanced artificial intelligence models for improving cardiovascular risk prediction and treatment response assessment in obstructive sleep apnea (OSA) patients. The research...
- The National Heart, Lung, and Blood Institute awarded The Trustees of the University of Pennsylvania $1.542 million on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to improve understanding of sleep apnea pathogenesis using novel imaging techniques during sleep. The research combines drug-induced sleep endoscopy (DISE) with dynamic magnetic resonance imaging (MRI) to characterize upper airway anatomy and the mechanisms of airway collapse during sleep. The...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital $171,600 on September 1, 2026, under CFDA 93.837 (Cardiovascular Diseases Research) to support career development and mentored research in pediatric obstructive sleep apnea diagnostics. The award funds the recipient investigator's training in three areas: predictive modeling and machine learning, advanced physiological signal analysis, and implementation science for translating research into clinical...
- The Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health awarded Icahn School of Medicine at Mount Sinai $249,871 on September 1, 2026, to improve World Trade Center responder mental health through precision treatment of comorbid insomnia and sleep apnea under CDC Investigations and Technical Assistance (CFDA 93.283). The project runs through August 31, 2028, with performance in New York, New York. The award funds research and clinical intervention...
- The National Heart, Lung, and Blood Institute awarded Icahn School of Medicine at Mount Sinai $170,892 on June 22, 2026, to support Dr. Oren Cohen's mentored training in machine learning and artificial intelligence applied to cardiovascular research through the Cardiovascular Diseases Research program (CFDA 93.837). The award funds development of causal machine learning models to identify which obstructive sleep apnea (OSA) patients will benefit from CPAP therapy for reduction of...
- The National Heart, Lung, and Blood Institute awarded the Research Foundation For Mental Hygiene, Inc., operating through its New York State Psychiatric Institute, $261,716 on July 22, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to adapt and pilot a doula-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention for pregnant individuals experiencing prenatal sleep disturbances. The project addresses the gap between evidence-based CBT-I treatment efficacy...
- The National Heart, Lung, and Blood Institute awarded Icahn School of Medicine at Mount Sinai $762,006 on September 15, 2025, to develop and test an integrated intervention combining asthma self-management support with cognitive behavioral therapy for depression in older adults with uncontrolled asthma and comorbid depression. The award funds development of a 10–12 session integrated program (SAMBA-CBT-AD) designed to address depression as a barrier to asthma medication adherence and...
- The National Heart, Lung, and Blood Institute awarded Icahn School of Medicine at Mount Sinai $672,958 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on task-shifting models for hypertension care in low-resource rural settings. The research project, titled "Task-Shifting at the Doorstep of the People: Strengthening the Hypertension Care Continuum Within Primary Health Care in a Low-Resource Setting," develops and tests...
The National Heart, Lung, and Blood Institute awarded the Icahn School of Medicine at Mount Sinai $193,467 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support career development and a pilot prospective randomized clinical trial examining sleep restriction therapy for co-morbid insomnia and sleep apnea (COMISA). The award funds Dr. Thomas M. Tolbert's transition to career independence as a physician-scientist studying the heterogeneous pathophysiology of COMISA. Dr. Tolbert will lead a pilot trial, complete didactic coursework, and receive mentorship from Dr. Indu Ayappa, an internationally recognized expert in sleep and respiratory physiology, and Dr. Nancy Redeker, expert in behavioral sleep research. The research plan aims to improve understanding of how insomnia and sleep apnea interact, with particular focus on mechanistic alternatives to positive airway pressure (PAP) therapy, the current first-line treatment for sleep apnea that shows poor tolerability in many COMISA patients. Dr. Tolbert's long-term goal is to become a foremost expert on COMISA and conduct mechanistic trials to advance treatment approaches. The award period runs through July 31, 2031, with place of performance in New York, New York. The assistance type is a Project Grant, which provides support for specific, well-defined research and career development activities rather than institutional block funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $193.5k | 8/3/26 |