Project Grant K23HL183847
- Federal Grant Award Summary The University of Michigan received a $1,494,562 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 20, 2025, with a completion date of June 30, 2030. The research initiative will develop an in situ micro-rheology technique utilizing ultrasound-responsive nanodroplets to characterize aging thrombi (blood clots) in real-time and non-invasively. The primary...
- Federal Grant Award Summary The University of Michigan received a $619,882 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective July 5, 2025, with completion targeted for April 30, 2030. The grant funds a mechanistic clinical trial designed to personalize heart failure treatment through genomic analysis. The research will prospectively validate a polygenic risk score (PRS) for predicting...
- Federal Grant Award Summary The University of Michigan received a $247,702 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) for research investigating the role of high-fat diet in hematopoiesis and clonal hematopoiesis. The award, effective July 9, 2025, through January 31, 2028, supports fundamental research examining how dietary factors influence hematopoietic stem cell (HSC) function and the...
- Federal Project Grant Award Summary The University of Michigan received a $304,007 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 18, 2025, with completion targeted for December 31, 2027. The project, "Leveraging a 'Sliding-Window' Type I CRISPR Base Editing Platform to Correct CFTR Null Mutations," delivers research and development services focused on advancing a novel gene-editing...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $429,000 Project Grant to the Regents of the University of Michigan on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a rapid, non-contrast, low-field magnetic resonance imaging (MRI) pipeline for detecting pulmonary embolism (PE). The project, which extends through July 31, 2027, focuses on creating an efficient 3D, contrast-free MRI protocol utilizing...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Michigan a $1,380,474 Project Grant effective September 24, 2025, through July 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). The OPTIBED (Optimizing the Care of Acute Heart and Lung Diseases through Precision Triage and Inpatient Bed Assignment) project addresses critical mortality disparities in acute cardiac and pulmonary care by developing data-driven...
- Federal Project Grant Award Summary The University of Michigan received a $207,342 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 12, 2025, through June 30, 2030. The award funds the Michigan Emergency Medicine Physician-Scientist Structured Research Training and Research (STARR) Training Program, which provides specialized research training and career development for emergency...
- Federal Project Grant Award Summary The University of Michigan received $733,439 in federal funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) for a project titled "Sexually Dimorphic Mechanisms in Human Thoracic Aortic Aneurysm." The award, dated September 5, 2025, with completion scheduled for June 30, 2029, supports basic and translational research aimed at understanding sex-based differences in...
- Federal Grant Award Summary Michigan Technological University received a $410,956 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2028. The award supports research titled "Stratifying Thrombosis Risk in Kawasaki Disease Using Hemodynamic Analysis Beyond the Z-Score," which addresses the clinical challenge of identifying thrombotic risk in patients...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Michigan a Project Grant totaling $100,228 under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on the role of Toll-Like Receptor-9 (TLR9) in lung structural cells during influenza and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. The award, obligated on December 1, 2026, with an ultimate completion date of April 30, 2029, will support...
The University of Michigan received a $191,629 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on May 15, 2026, with completion targeted for April 30, 2031. This research initiative addresses venous thromboembolism (VTE) prevention and management in pregnant and postpartum patients with sickle cell disease (SCD), a medically vulnerable population experiencing maternal mortality rates 10 to 26 times higher than the general population. The project deliverables encompass three primary research aims: (1) establishing a data repository to determine VTE and bleeding incidence rates in pregnant and postpartum SCD patients, accounting for disease genotype and thromboprophylaxis use; (2) eliciting patient preferences regarding thromboprophylaxis through semi-structured interviews and discrete choice experiments to inform clinical guideline development; and (3) assessing the feasibility of enrolling and retaining postpartum SCD patients in a randomized controlled trial comparing thromboprophylaxis versus usual care. These foundational outputs will generate evidence and methodological frameworks necessary to support a subsequent Phase 3 clinical trial, ultimately enabling standardized VTE and bleeding prevention protocols to improve maternal outcomes in this high-risk patient population.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $191.6k | 5/18/26 |