The University of Texas Southwestern Medical Center (UT Southwestern) received a $156,600 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a 5-year research and career development plan for Dr. Glynnis Garry, a cardiovascular physician-scientist, to characterize the role of the histone reader PHF7 in mediating cardiac reprogramming as a potential therapeutic approach for ischemic heart disease. The research aims to 1) define PHF7's function in adult human reprogramming, 2) evaluate the ability of PHF7 to improve cardiac function after myocardial infarction, and 3) delineate the mechanisms by which PHF7 drives reprogramming and cardiac function improvement. This work could provide the basis for developing a novel therapeutic factor for treating ischemic heart disease and enhance understanding of cardiac reprogramming. The project is being conducted at UT Southwestern under the mentorship of Dr. Eric Olson, a leading expert in cardiovascular regeneration.
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